Kolchin 0.6

Indications

Kolchin is prescribed for:

• Acute Gout Flares: Effective in treating sudden gout attacks.
• Familial Mediterranean Fever (FMF): Suitable for both adults and children aged 4 years and older.

Always consult a registered healthcare professional before use.

Description

Kolchin is an FDA-approved medication designed to alleviate gout symptoms and prevent future attacks. Gout occurs when uric acid crystals accumulate in joints, leading to inflammation. Kolchin works by inhibiting the migration of white blood cells to these areas, thereby reducing pain and inflammation.

Pharmacology

Gout attacks stem from an inflammatory response to urate crystals in the joints. Kolchin prevents this inflammation by inhibiting white blood cell phagocytosis of uric acid and decreasing lactic acid production, effectively breaking the cycle of crystal deposition and inflammation.

Dosage & Administration

• For Acute Gout: Start with 1 to 1.2 mg (two 0.5 mg or two 0.6 mg tablets) every 2 hours, until symptoms improve. Total dosage typically ranges from 4 to 8 mg.
• For Prophylaxis: For infrequent attacks, 0.5 or 0.6 mg daily, 3-4 times a week. For frequent attacks, 0.5 or 0.6 mg daily, with severe cases requiring 2-3 tablets daily.
• Surgical Prophylaxis: Administer one tablet (0.5 mg or 0.6 mg) three times daily for three days before and after surgery.

Consult a registered healthcare professional for tailored advice.

Interactions

Co-administration with P-gp and/or CYP3A4 inhibitors (like clarithromycin or cyclosporine) can affect Kolchin levels.

Contraindications

Not suitable for patients with renal or hepatic impairment who are taking strong CYP3A4 or P-gp inhibitors.

Side Effects

Potential side effects include:

• Common: Diarrhea, pharyngolaryngeal pain
• Serious: Myelosuppression, leukopenia, thrombocytopenia, aplastic anemia

Pregnancy & Lactation

Kolchin is classified as Pregnancy Category C. Caution is advised for nursing mothers, as the drug is excreted in breast milk.

Special Populations

Pediatric Use: Safety and effectiveness in children have not been established, as gout is rare in this population.

Overdose Effects

Toxicity levels for Kolchin vary; serious effects can occur at doses as low as 7 mg. Patients ingesting more than 60 mg have survived, while milder symptoms were noted in those consuming under 0.5 mg/kg.

Therapeutic Class

Drugs used for the treatment of gout.

Storage Conditions

Store below 30°C, shielded from light and moisture. Keep out of reach of children.