Indications
Moxifloxacin & Dexamethasone eye drop is prescribed for treating eye infections caused by susceptible microorganisms and preventing inflammation and bacterial infection post-eye surgery.
Composition
Each ml contains:
- Moxifloxacin Hydrochloride BP equivalent to Moxifloxacin 5 mg
- Dexamethasone Sodium Phosphate USP equivalent to Dexamethasone Phosphate 1 mg.
Pharmacology
Moxifloxacin inhibits both topoisomerase II (DNA gyrase) and topoisomerase IV, essential enzymes involved in bacterial DNA replication and repair. Dexamethasone, a cortisone derivative, exhibits anti-allergic, anti-exudative, and anti-proliferative properties by inhibiting phospholipase A2 and neutrophil chemotaxis.
Dosage & Administration
For infection prevention and post-surgical ocular inflammation: Instill 1 drop, 4 times a day, in the eye to be operated, from 1 day before surgery until 15 days after surgery.
Contraindications
Avoid in patients with hypersensitivity to other quinolones, glaucoma, ocular diseases causing corneal or scleral thinning, and viral or fungal eye conditions.
Side Effects
Moxifloxacin may cause conjunctivitis, decreased visual acuity, and dry eye, while Dexamethasone can lead to cataract formation and secondary ocular infections.
Pregnancy & Lactation
Use during pregnancy or lactation should be considered only if the potential benefit outweighs the risk to the fetus or infant.
Precautions & Warnings
Discontinue use if allergic reaction occurs, monitor intraocular pressure regularly, and avoid prolonged steroid use to prevent ocular complications.
Use in Special Populations
No dosage adjustment is required for elderly patients, but efficacy and safety in pediatric patients have not been established.
Overdose Effects
No information is available on overdosage in humans.
Therapeutic Class
Ophthalmic Steroid preparations
Storage Conditions
Store below 30°C, protected from light, and discard after 28 days of opening. Keep out of reach of children.
Brand
Generics
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