Indever 20

Indications

Indever (Propranolol Hydrochloride) is prescribed for the management of a variety of health conditions, including:

• Essential Hypertension (High Blood Pressure)
• Angina Pectoris (Chest Pain)
• Cardiac Arrhythmia (Irregular Heartbeat)
• Thyrotoxicosis (Excessive Thyroid Hormones)
• Anxiety
• Migraine Prophylaxis (Prevention of Migraines)

Always consult with a registered healthcare provider before starting treatment.

Pharmacology

Indever contains Propranolol Hydrochloride, a beta-adrenergic blocker commonly used in the treatment of hypertension and angina. It works by blocking the effects of catecholamines at beta-adrenergic receptors, thereby reducing heart rate, preventing excessive force of heart contractions, and decreasing oxygen consumption by the heart.

Propranolol is efficiently absorbed in the gastrointestinal tract and reaches peak plasma concentration within 1 to 1.5 hours after oral administration. The plasma half-life ranges from 3 to 6 hours, and the metabolites are excreted via the urine.

Dosage & Administration

Adult Dosage (18 years and older):

• Hypertension: Start with 80 mg twice daily. Can be increased weekly, with a maintenance dose of 160-320 mg daily.
• Angina Pectoris: Start with 40 mg 2-3 times daily, then adjust to 120-240 mg daily for maintenance.
• Thyrotoxicosis: 10-40 mg, 3-4 times daily.
• Anxiety: Start with 40 mg once daily, can be increased to 3 times daily.
• Migraine Prevention: Start with 40 mg 2-3 times daily, increase to 80-160 mg daily as a maintenance dose.

Pediatric Dosage (1 day to 18 years):

• Neonates: 0.25-0.5 mg/kg 3 times daily, adjust as needed.
• Children (1 month to 12 years): 0.25-1 mg/kg 3 times daily, maximum 5 mg/kg daily.
• Adolescents (12-18 years): Start with 80 mg twice daily, maintenance dose 160-320 mg daily.

Consult with a healthcare professional for proper dosage and recommendations.

Drug Interactions

Be cautious when administering Indever with the following medications:

• Verapamil
• Salbutamol
• Levosalbutamol
• Ergot Alkaloids
• Lidocaine
• Phenobarbital

Close monitoring is recommended for patients on these drugs.

Contraindications

Indever should not be used in patients with:

• Bronchospasm
• Cardiogenic Shock
• Second or Third Degree Heart Block
• Diabetes Mellitus

Side Effects

Common side effects include:

• Cold extremities
• Nausea
• Dizziness
• Insomnia
• Paresthesia (tingling sensation)

Pregnancy & Lactation

Indever is categorized as Pregnancy Category C, meaning it should only be used during pregnancy if the potential benefit outweighs the risk to the fetus. Propranolol is excreted in breast milk, so caution is advised when administered to nursing mothers.

Precautions & Warnings

Use Indever with caution in patients with hepatic or renal impairment, and in pregnant or lactating women. Always follow medical guidance for proper use.

Therapeutic Class

• Beta-adrenergic Blocking Drugs (Beta-blockers)

Storage Conditions

Store Indever in a cool and dry place, away from light, and out of reach of children.