Glyset R Penset

Indications

• Glycemic Control: Indicated for improving glycemic control in patients with diabetes mellitus.
• Usage: Administration should be based on registered medical advice.

Composition

• Insulin Aspart: Each ml contains 100 IU (equivalent to 3.50 mg).

Description

• Formulation: Sterile, clear solution of Glyset R for subcutaneous or intravenous injection.
• Mechanism: Blood glucose lowering agent with a rapid onset of action compared to regular human insulin. It is a recombinant DNA technology product with a single amino acid substitution (Proline to Aspartic Acid at B28).

Pharmacology

• Function: Regulates glucose metabolism by binding to insulin receptors on muscle and fat cells, facilitating glucose uptake and inhibiting liver glucose output.

Dosage

• General Guidelines:
  • Administer immediately before meals.
  • Individual dosage is determined by physician advice, generally between 0.5 and 1.0 IU/kg/day for adults and children over 2 years.
  • 50-70% of meal-related insulin needs may be covered by Insulin Aspart, with the remainder from long-acting insulin.
• Administration Methods:
  • Subcutaneous Injection: In the abdomen, buttocks, thigh, or upper arm; inject 5-10 minutes before meals.
  • Continuous Subcutaneous Insulin Infusion (CSII): Via an external pump; do not mix with other insulins.
  • Intravenous Use: Administer under medical supervision with close monitoring of blood glucose and potassium levels.

Administration Instructions

1. Follow ConviPen instructions for cartridge insertion and needle attachment.
2. Gently mix the insulin by inverting the pen 8-10 times.
3. Remove the needle cap and expel air bubbles.
4. Adjust dosage and inject at the specified site.
5. Avoid cross-contamination by keeping the needle sterile.

Interactions

• Substances Reducing Insulin Requirements:
  • Oral anti-diabetic agents, ACE inhibitors, certain antibiotics, and more.
• Substances Increasing Insulin Requirements:
  • Thiazides, glucocorticoids, thyroid hormones, and others.
• Caution: Beta-blockers, clonidine, and alcohol may affect insulin’s effectiveness.

Side Effects

• Common: Hypoglycemia, allergic reactions, injection site reactions, lipodystrophy, pruritus, and rash.

Pregnancy & Lactation

• Category: B (No restrictions during lactation; dosage adjustments may be needed).

Precautions & Warnings

• Regular blood glucose monitoring is essential; dose adjustments should be made cautiously under medical supervision.

Overdose Effects

• Hypoglycemia: Mild cases treated with glucose; severe cases requiring glucagon (0.5 to 1 mg) or intravenous glucose.

Therapeutic Class

• Type: Rapid Acting Insulin.

Storage Conditions

• Store between 2°C to 8°C (refrigerate), avoid freezing, and protect from light.

Additional Note

• Always consult a registered physician for advice on medication usage.