Gelora Gel

Indications

Gelora Oral Gel:

• Effective for treating oral and gastrointestinal candidiasis.
• Eliminates fungal colonization in the mouth and gastrointestinal tract.
• Treats super infections caused by gram-positive bacteria.

Gelora Cream:

• Indicated for dermatomycoses such as Athlete’s foot, Tinea corporis, and Tinea manuum.
• Effective against fungal infections including Tinea pedis and Tinea cruris.
• Also treats Candidial infections, Tinea versicolor, and various skin infections.

Pharmacology

Pharmacodynamics: Miconazole in Gelora exhibits potent antifungal activity against common dermatophytes and yeasts. It also possesses antibacterial properties targeting specific gram-positive bacteria. Its mechanism involves inhibiting ergosterol biosynthesis, crucial for fungal cell membrane integrity, leading to cell death.

Pharmacokinetics: Miconazole’s oral bioavailability is low due to poor intestinal absorption. It binds significantly to plasma proteins and undergoes extensive metabolism, with minimal excretion unchanged in urine. The drug’s half-life is approximately 20-25 hours, consistent across patients including those with renal impairment.

Dosage

• Miconazole Oral Gel: Administered in specified doses for oropharyngeal and gastrointestinal candidosis, adjusted based on age and condition.
• Miconazole Cream: Applied twice daily for most dermatomycoses, with variations for specific conditions like Tinea versicolor.

Administration

Apply Miconazole gel directly to affected areas, ensuring prolonged contact for optimal efficacy. Treatment duration should extend beyond symptom relief for comprehensive recovery.

Interaction

Avoid concurrent use of Gelora with medications like Terfenadine and Cisapride, which Gelora may affect metabolically. Monitor phenytoin and cyclosporine levels during concomitant use to prevent toxicity.

Contraindications

Avoid Gelora in individuals with known hypersensitivity to Miconazole.

Side Effects

Possible adverse effects include nausea, vomiting, and allergic reactions in rare cases.

Pregnancy & Lactation

Use of Miconazole oral gel during pregnancy or lactation requires careful consideration of risks versus benefits, due to limited safety data.

Precautions & Warnings

Exercise caution in children to prevent gel obstruction in the throat. Monitor anticoagulant and phenytoin levels when co-administering Gelora.

Overdose Effects

Symptomatic treatment is recommended for accidental overdose, which may result in gastrointestinal symptoms.

Therapeutic Class

Gelora falls under the category of Aural Anti-fungal preparations.

Storage Conditions

Store Gelora in a dry place away from light and heat, and out of children’s reach.

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