Flurium 5

Indications

Florium is indicated for the following conditions:

• Migraine Prevention: Effective for both classic (with aura) and common (without aura) migraines.
• Vestibular Vertigo: Symptomatic treatment for vertigo due to diagnosed vestibular system disorders.
• Peripheral Vascular Disease (PVD): Helps manage symptoms associated with PVD.
• Motion Sickness: Provides relief from motion-induced nausea and discomfort.
• Refractory Epilepsy: Assists in managing epilepsy that does not respond to conventional antiepileptic medications.

Use only under the guidance of a registered physician.

Description

Florium contains Flunarizine, a difluorinated derivative of cinnarizine. As a selective calcium channel antagonist, it reduces excessive calcium influx in cells, preventing overload while maintaining normal calcium balance. Flunarizine also exhibits mild antihistaminic and sedative effects, with a high affinity for plasma proteins.

Dosage & Administration

Migraine Prophylaxis:

• Starting Dose:
  • Adults under 65: 10 mg at night
  • Adults over 65: 5 mg daily
• Maintenance Treatment: If effective, reduce to 5 days of treatment with two consecutive drug-free days each week. After 6 months, consider discontinuation if symptoms do not relapse.

Peripheral Vascular Disease: 10 mg twice daily, adjustable to 30 mg per day if necessary.

Vertigo & Motion Sickness:

• Adults: 10-20 mg daily
• Children (> 40 kg): 5 mg daily

Epileptic Seizures:

• Adults: 15-20 mg daily
• Children: 5-10 mg daily as adjunct therapy.

Use only under the guidance of a registered physician.

Interactions

Some women on oral contraceptives may experience galactorrhea within the first two months of treatment. Hepatic enzyme inducers like carbamazepine and phenytoin may enhance the metabolism of Florium, potentially necessitating dosage adjustments.

Contraindications

Do not use in individuals with hypersensitivity to Flunarizine, a history of depression, or pre-existing Parkinson’s disease or other extrapyramidal disorders.

Side Effects

Common side effects may include drowsiness, fatigue, weight gain, and increased appetite. Chronic use may lead to depression, particularly in those with a history of depressive disorders, and extrapyramidal symptoms, especially in the elderly. Less frequent reactions include heartburn, nausea, gastralgia, insomnia, anxiety, galactorrhea, dry mouth, muscle aches, and skin rashes.

Pregnancy & Lactation

The safety of Florium during pregnancy and lactation has not been established. Use with caution.

Precautions & Warnings

Florium may cause drowsiness, particularly when combined with alcohol or other CNS depressants. Caution is advised when driving or performing tasks requiring alertness. It is not intended for aborting migraine attacks, and dosage should not be increased in anticipation of an attack. Use with caution in elderly patients and those predisposed to extrapyramidal or depressive symptoms.

Therapeutic Class

Miscellaneous prophylactic migraine preparations.

Storage Conditions

Store below 30°C, away from light and moisture. Keep out of reach of children.