Flubex 500

Indications

Flubex is prescribed for various infections caused by Gram-positive bacteria, including those resistant to penicillinase. Key uses include:

• Skin and Soft Tissue Infections: Treats conditions like boils, abscesses, eczema, acne, cellulitis, infected wounds, and burns.
• Respiratory Tract Infections: Effective against pneumonia, lung abscess, empyema, sinusitis, and pharyngitis.
• Other Infections: Manages osteomyelitis, endocarditis, urinary tract infections, and meningitis. Also used prophylactically in major surgeries, such as cardiothoracic and orthopedic procedures.

Pharmacology

Flucloxacillin is a penicillinase-resistant antibiotic effective against Gram-positive organisms. It disrupts bacterial cell wall synthesis by inhibiting transpeptidase enzymes, which are crucial for cell wall stability. This action weakens the bacterial cell wall, leading to cell rupture. Flucloxacillin is resistant to penicillinase due to its structural modifications.

Dosage

• Oral: Adults take 250 mg four times daily, with possible increase in severe infections (up to 8 g/day). Children’s doses are adjusted by age.
• Parenteral: For adults and elderly, options include intramuscular and intravenous injections, with dosage based on infection severity. Children receive reduced doses.

Administration

• Oral: Take 1 hour before meals.
• IV: Dilute and administer as per guidelines for intermittent or continuous infusion.

Interactions

Flubex may interact with other medications, potentially increasing its blood levels or affecting drug metabolism.

Contraindications

Avoid use in patients with penicillin allergies.

Side Effects

Common side effects include gastrointestinal issues like nausea and diarrhea. Serious reactions might involve skin rashes, fever, or liver problems.

Pregnancy & Lactation

Flubex is classified as FDA Pregnancy Category B. Use during pregnancy only if necessary. It is excreted in breast milk, so caution is advised when used by lactating mothers.

Precautions

Monitor liver function and use cautiously in patients with allergic conditions. Adjust dosages in severe renal failure.

Therapeutic Class

Penicillinase-resistant penicillins.

Storage Conditions

Store in a dry, cool place away from light and heat. Keep out of reach of children.