Fixolin 200

Indications:

Fixolin is prescribed for:

• Bronchial asthma
• Bronchospasm
• Chronic obstructive pulmonary disease (COPD)
• Pulmonary diseases with a spastic bronchial component

Pharmacology:

Doxophylline, a novel bronchodilator, selectively inhibits phosphodiesterase 4, relaxing bronchial smooth muscle without affecting adenosine receptors like Theophylline. It also inhibits platelet activating factor (PAF) and leukotriene production.

Dosage & Administration:

For Elderly: Take 200 mg tablet two or three times daily. For Adults: Take 400 mg tablet two or three times daily, or as directed. For Children:

• 12 years: 10 ml syrup or 200 mg tablet two or three times daily.

• 6-12 years: 6-9 mg/kg body weight twice daily.

Interaction:

Avoid concurrent use with xanthine preparations or caffeine-containing products. Caution with sympathomimetic drugs and drugs affecting hepatic metabolism.

Contraindications:

Avoid in hypersensitivity to doxophylline or xanthine derivatives, acute myocardial infarction, hypotension, and lactation.

Side Effects:

Possible side effects include nausea, vomiting, headache, and cardiac symptoms. Discontinue in case of severe reactions.

Pregnancy & Lactation:

Contraindicated during pregnancy and lactation due to insufficient clinical data.

Precautions & Warnings:

Monitor patients with hepatic impairment, congestive heart failure, and other conditions affecting drug metabolism closely.

Overdose Effects:

May cause severe cardiac arrhythmias and seizures; manage symptoms symptomatically.

Therapeutic Class:

Bronchodilator, Methyl xanthine derivatives

Storage Conditions:

Store in a dry place, away from light and heat, and out of the reach of children. Use only under specialist physician’s prescription.