Edopain 300

Indications

Edopain is recommended for:

• Managing both acute and chronic symptoms of osteoarthritis and rheumatoid arthritis
• Alleviating acute pain
• Treating acute gout

Description

Edopain is a nonsteroidal anti-inflammatory drug (NSAID) known for its anti-inflammatory, analgesic, and antipyretic properties. Its effectiveness stems from inhibiting prostaglandin synthesis, a common mechanism among NSAIDs.

Pharmacology

Edopain’s anti-inflammatory effects arise from its inhibition of the cyclooxygenase (COX) enzyme, which decreases the production of peripheral prostaglandins that mediate inflammation. Unlike traditional NSAIDs, Edopain is 5-50 times more selective for COX-2 than COX-1. It may also lower fever by acting on the hypothalamus, promoting peripheral dilation and enhancing heat loss.

Dosage & Administration

Adults (18 years and older):

• Etodolac 300 mg capsules: 600 mg daily, divided into 1-2 doses
• Etodolac 600 mg extended-release tablets: Once daily

Pediatric Use: Safety and effectiveness in patients under 18 years have not been established.

Always follow your healthcare provider’s advice.

Interactions

NSAIDs, including Edopain, may reduce the effectiveness of ACE inhibitors. Caution is advised when using Edopain with Aspirin, as it can alter protein binding without affecting clearance. Concomitant use is generally not recommended due to the potential for increased adverse effects.

Contraindications

Edopain is contraindicated in individuals with known hypersensitivity to the drug. It should not be used by patients who have experienced asthma, urticaria, or other allergic reactions following Aspirin or NSAID use.

Side Effects

Common side effects of Edopain include gastrointestinal issues such as abdominal pain, constipation, diarrhea, dyspepsia, flatulence, heartburn, nausea, gastric ulcers, and vomiting. Other potential effects include dizziness, edema, elevated liver enzymes, headaches, increased bleeding time, pruritus, rashes, and tinnitus.

Pregnancy & Lactation

There are no well-controlled studies of Edopain in pregnant women. It should only be used during pregnancy if the benefits outweigh the risks. The excretion of Edopain in human milk is unknown, so a decision should be made to either discontinue nursing or the drug based on its importance to the mother.

Precautions & Warnings

Caution is advised for patients with severe hepatic conditions, pre-existing asthma, fluid retention, hypertension, or heart failure. Discontinue Edopain if signs of liver disease or systemic reactions (e.g., eosinophilia, rash) occur.

Overdose Effects

Acute overdose of Edopain may result in symptoms such as lethargy, drowsiness, nausea, vomiting, and epigastric pain, which are typically reversible with supportive care.

Therapeutic Class

• Drugs for Osteoarthritis
• Drugs for Rheumatoid Arthritis
• Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

Store below 30°C, away from light, and keep out of reach of children.