Ebasten

Indications

Ebasten is recommended for the effective management of:

• Seasonal and perennial allergic rhinitis: Relieves symptoms of allergies like sneezing, runny nose, and itching.
• Chronic idiopathic urticaria: Helps manage symptoms of chronic hives.

Consult with a registered healthcare professional before using this medication.

Pharmacological Action

Ebasten is a long-acting, selective H1-histamine receptor blocker that provides relief from allergy symptoms. It inhibits peripheral receptors consistently, even with prolonged use. Upon oral administration, Ebasten is rapidly absorbed and undergoes significant first-pass metabolism, converting almost entirely into carebastine, its active pharmacological form.

Dosage & Administration

Tablet:

• Adults (12 years and older): 10 mg (1 tablet) once daily.
• Children (6-12 years): 5 mg (½ tablet) once daily.

Syrup:

• Children (2-5 years): 2.5 ml once daily (up to 5 ml for severe cases like perennial allergic rhinitis).
• Children (6-12 years): 5 ml once daily (up to 10 ml for severe cases).

Ebasten can be taken with or without food. Consult with a registered healthcare professional before using this medication.

Drug Interactions

Taking Ebasten with ketoconazole or erythromycin may increase its plasma levels and prolong the QTc interval. Ebasten does not affect the metabolism of drugs such as theophylline, warfarin, cimetidine, diazepam, or alcohol, though the sedative effects of alcohol and diazepam may be amplified.

Contraindications

Ebasten is contraindicated in individuals who have a known allergy or hypersensitivity to Ebastine or any of its ingredients.

Side Effects

The most common side effects of Ebasten include:

• Headache
• Dry mouth
• Drowsiness

Less frequent side effects may include:

• Abdominal pain
• Dyspepsia (indigestion)
• Nausea
• Insomnia

Overdose Management

No significant symptoms or signs of toxicity have been observed even with a dose of 100 mg taken once daily. There is no specific antidote for Ebasten. In the case of overdose, gastric lavage, monitoring vital signs (including ECG), and symptomatic treatment should be provided.

Therapeutic Classification

• Non-sedating antihistamine

Storage Instructions

• Store Ebasten at temperatures below 30°C in a cool, dry place, away from direct light.
• Keep out of the reach of children.