Dynase

Indications

Dynase Nasal Spray is designed to alleviate the symptoms of seasonal allergic rhinitis in individuals aged 6 years and older. It combines the benefits of Azelastine Hydrochloride and Fluticasone Propionate to provide effective symptomatic relief.

Pharmacology

Azelastine Hydrochloride functions as an H1-receptor antagonist, targeting histamine activity in isolated tissues. Its primary metabolite, desmethylazelastine, also exhibits H1-receptor antagonist properties. Fluticasone Propionate, a synthetic trifluorinated corticosteroid, offers anti-inflammatory benefits. Although the exact mechanism by which Fluticasone Propionate alleviates allergic rhinitis symptoms is not fully understood, corticosteroids like Fluticasone Propionate influence a variety of cell types and mediators involved in inflammation, including mast cells, eosinophils, neutrophils, macrophages, lymphocytes, histamine, eicosanoids, leukotrienes, and cytokines.

Dosage

• Adults: One spray per nostril twice daily.
• Pediatrics: The safety and efficacy of Dynase Nasal Spray in children under 6 years of age have not been established.

Always follow your healthcare provider’s instructions when using this medication.

Administration

To use the Nasal Spray:

1. Gently shake the bottle and remove the dust cover.
2. Hold the spray with your forefinger and middle finger on either side of the nozzle, and your thumb underneath the bottle. Press down until a fine mist appears. If using for the first time or after a period of disuse, pump the applicator several times until a fine mist emerges.
3. Clear your nostrils by gently blowing your nose.
4. Close one nostril and insert the nasal applicator into the open nostril. Tilt your head slightly forward, keeping the spray upright. Breathe in through your nose while pressing the applicator’s collar firmly to release a spray.
5. Exhale through your mouth.
6. Repeat the process for the other nostril.

Cleaning Instructions:

• Remove the dust cover.
• Gently detach the nasal applicator.
• Wash the applicator and dust cover with warm water.
• Shake off excess water and let them air dry. Avoid applying heat.
• Reattach the applicator and dust cover.

Always follow your healthcare provider’s instructions when using this medication.

Contraindications

Currently, there are no known contraindications for Dynase Nasal Spray.

Side Effects

Common side effects (occurring in >2% of users) may include dysgeusia, epistaxis, and headache.

Pregnancy & Lactation

• Pregnancy: Category C. There are no well-controlled studies in pregnant women. Use only if the potential benefits justify the risks to the fetus.
• Lactation: It is unknown whether Dynase Nasal Spray is excreted in breast milk. Caution is advised when administering to nursing mothers.

Precautions & Warnings

Avoid engaging in activities requiring full mental alertness, such as driving or operating machinery, while using this nasal spray. Avoid concurrent use with alcohol or other CNS depressants to prevent further impairment. High doses or prolonged use may cause hypercorticism or adrenal suppression. Discontinue the spray gradually if such effects occur.

Overdose Effects

No significant adverse events have been reported with Azelastine Hydrochloride overdose, other than increased somnolence. Chronic overdose of Fluticasone Propionate may lead to symptoms of hypercorticism.

Therapeutic Class

Nasal Steroid Preparations

Storage Conditions

Store below 25°C, away from light. Do not refrigerate. Keep out of reach of children.