Deflux 10

Indications

Dyspeptic Symptoms: Effective for addressing discomforts related to delayed gastric emptying, gastroesophageal reflux, and esophagitis, including:

• • Fullness and distension in the upper abdomen
  • Abdominal pain
  • Eructation and flatulence
  • Early satiety
  • Nausea and vomiting
  • Heartburn with or without gastric content regurgitation
  • Non-ulcer dyspepsia
• Acute Nausea and Vomiting: Useful for nausea and vomiting from various causes including functional, organic, infectious origins, diet, radiotherapy, or drug treatments, as well as migraine-induced nausea.
• Parkinson’s Disease: Manages dopamine-agonist induced nausea and vomiting.
• Radiological Studies: Enhances barium transit speed in follow-through radiological assessments.

Pharmacology

Domperidone: A dopamine antagonist primarily targeting dopamine receptors in the Chemoreceptor Trigger Zone (CTZ) and stomach. It promotes gastrointestinal motility and facilitates gastric emptying by blocking dopamine receptors that influence gut motility. Due to its limited ability to cross the blood-brain barrier, it minimizes psychotropic and neurological side effects. It also boosts esophageal peristalsis and lower esophageal sphincter pressure, preventing regurgitation.

Dosage & Administration

• Tablets:
  • Adults: 10-20 mg every 6-8 hours (maximum 80 mg daily).
  • Children: 2-4 ml suspension/10 kg body weight or 0.4-0.8 ml pediatric drops/10 kg body weight every 6-8 hours.
• In Dyspeptic Symptoms:
  • Adults: 10-20 mg every 6-8 hours.
  • Children: 0.2-0.4 mg/kg body weight every 6-8 hours.
• Acute Conditions:
  • Adults: 20 mg every 6-8 hours (maximum treatment duration 12 weeks).
  • Children: 0.2-0.4 mg/kg body weight every 6-8 hours (maximum treatment duration 12 weeks).
• Rectal Suppositories:
  • Adults: 30-60 mg every 4-8 hours.
  • Children: Maximum daily dose is 30 mg for those weighing 10 to 25 kg.

Interaction

• Anticholinergics: May reduce the effectiveness of Domperidone.
• CYP3A4 Inhibitors: Azole antifungals, macrolide antibiotics, and protease inhibitors may increase Domperidone levels.
• Other Medications: May influence the absorption of sustained release or enteric-coated drugs but generally does not affect established drugs like digoxin or paracetamol.

Contraindications

• Hypersensitivity: Not suitable for those with known hypersensitivity to Domperidone.
• Gastrointestinal Risks: Avoid use in conditions like gastrointestinal hemorrhage, obstruction, or perforation.
• Prolactinoma: Contraindicated in patients with prolactin-releasing pituitary tumors.

Side Effects

• Common: Headache, breast discomfort, mood changes, and acne.
• Less Common: Gastrointestinal issues, weight increase, and mood alterations.
• Rare: Extrapyramidal symptoms, increased prolactin levels, allergic reactions.

Pregnancy & Lactation

• Pregnancy: Use only in the first trimester if absolutely necessary. No evidence of increased malformation risk in humans.
• Lactation: Excreted in breast milk; consider discontinuing breastfeeding or the medication based on a risk-benefit assessment.

Precautions & Warnings

• Children: Use with caution due to potential risk of extrapyramidal reactions.
• Hepatic Impairment: Caution required for patients with liver issues.
• Infants: Use with great caution due to immature blood-brain barrier.
• Kidney Disorders: Adjust dosing frequency in severe renal insufficiency.

Overdose Effects

• Symptoms: Drowsiness, disorientation, and extrapyramidal reactions.
• Management: Activated charcoal and close observation recommended; anticholinergic or antiparkinson drugs may help manage extrapyramidal symptoms.

Therapeutic Class

Motility Stimulants, Dopamine Antagonists, Prokinetic Drugs

Storage Conditions

Store below 30°C, protected from light and moisture. Keep out of reach of children.