Indications
Deflacort serves a variety of purposes, including:
- Managing anaphylaxis, asthma, and severe hypersensitivity reactions
- Treating conditions such as rheumatoid arthritis, juvenile chronic arthritis, and polymyalgia rheumatica
- Addressing autoimmune disorders like systemic lupus erythematosus and dermatomyositis
- Managing gastrointestinal conditions like ulcerative colitis and Crohn’s disease
- Supporting patients with hematological disorders such as acute and lymphatic leukemia
Pharmacology
Deflazacort exerts its effects by inhibiting the Phospholipase A2 enzyme, which plays a role in prostaglandin synthesis. Additionally, it suppresses the release of certain immune system chemicals, providing immunosuppressive action.
Dosage & Administration
For adults, initial doses may vary depending on the condition, with maintenance doses typically ranging from 3-18 mg/day. Pediatric dosages are calculated based on weight and condition severity, with careful titration for optimal effectiveness.
Interactions
Deflacort metabolism occurs primarily in the liver, so co-administration with liver enzyme-inducing drugs may necessitate dose adjustments. Conversely, liver enzyme-inhibiting drugs may allow for reduced Deflacort maintenance doses.
Contraindications
Deflacort is contraindicated in individuals with hypersensitivity to its ingredients or those receiving live virus immunizations.
Side Effects
Possible side effects include gastrointestinal disturbances, musculoskeletal issues, endocrine disruptions, and susceptibility to infections. Careful monitoring is necessary to address these potential effects.
Pregnancy & Lactation
While Deflazacort can cross the placenta, its use during pregnancy should be carefully weighed against potential risks. Similarly, caution is advised for nursing mothers due to potential excretion in breast milk.
Precautions & Warnings
Patients with cardiac disease, hypertension, or thromboembolic disorders require special monitoring. Conditions such as gastritis, diabetes mellitus, or renal insufficiency may necessitate adjustments in treatment.
Use in Special Populations
Special considerations are advised for patients with hepatic or renal impairment, as well as elderly individuals, to ensure appropriate dosing and monitoring.
Therapeutic Class
Deflacort belongs to the class of glucocorticoids, known for their anti-inflammatory and immunosuppressive properties.
Storage Conditions
Store Deflacort in a cool, dry place, away from light and moisture, and out of reach of children.
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