D3 Oral Solution 15ml

Indications

• Vitamin D3 Deficiency: Individuals with limited sunlight exposure or poor dietary intake are at risk of Vitamin D3 deficiency. This condition is essential for effective calcium and phosphate absorption, which supports healthy bones and teeth. It helps prevent conditions like rickets, osteomalacia, and osteoporosis.
• Pregnancy & Breastfeeding: Vitamin D3 is crucial for preventing pre-eclampsia during pregnancy. It’s also vital for breastfeeding mothers, ensuring optimal nutrient intake for growing infants.
• Immune System Support: Vitamin D3 plays a significant role in boosting immune function, helping the body defend against infections.

Always consult a registered healthcare professional before taking any medication.

Pharmacology

Vitamin D3’s active form, Calcitriol, binds to Vitamin D receptors (VDRs) throughout the body, influencing a variety of physiological processes. As a fat-soluble vitamin, its half-life is approximately 50 days. After absorption in the small intestine, Vitamin D3 binds to specific a-globulins and is transported to the liver, where it is converted to 25-hydroxy Vitamin D3 (Calcidiol). A subsequent conversion to 1,25-dihydroxy Vitamin D3 (Calcitriol) takes place in the kidneys, which enhances calcium absorption. Unmetabolized Vitamin D3 is stored in tissues such as fat and muscle. The elimination process occurs via feces and urine.

Dosage & Administration

For Capsules:

• Adults:
  • Vitamin D3 Deficiency Treatment: 40,000 IU weekly for 7 weeks. Maintenance dose: 1,400–2,000 IU/day. Measure serum 25-hydroxyvitamin D levels 3–4 months after starting maintenance therapy.
  • Prevention: 20,000 IU every 4 weeks. Higher doses may be necessary depending on individual requirements.
  • Osteoporosis Management: 20,000 IU monthly.
• Children (12–18 years):
  • Vitamin D3 Deficiency Treatment: 20,000 IU every two weeks for 6 weeks.
  • Prevention: 20,000 IU every 6 weeks.

For Tablets (Film-Coated or Chewable):

• 1000 IU (1–2 tablets) daily or as directed by a healthcare provider. Take with food or within 1 hour of eating.

For Syrup:

• For Risk of Deficiency:
  • 0-1 year: 400 IU/day (2 mL).

  • 1 year: 600 IU/day (3 mL).

• For Deficient Patients:
  • 0-1 year: 2,000 IU/day (+50,000 IU/week) for 6 weeks.
  • 1-18 years: 2,000 IU/day for 6 weeks.

Injection:

• Prevention:
  • Infants on Vitamin D-enriched milk: ½ ampoule (1,000,000 IU) every 6 months.
  • Non-enriched milk or children under 5: 1 ampoule (2,000,000 IU) every 6 months.
  • Adolescents: 1 ampoule (2,000,000 IU) every 6 months during winter.
  • Pregnancy: ½ ampoule (1,000,000 IU) from the 6th or 7th month of pregnancy.
  • Elderly: ½ ampoule (1,000,000 IU) every 3 months.
• For Deficiency:
  • 1 ampoule (2,000,000 IU) with repeat doses as recommended by a healthcare provider.

Always follow your doctor’s guidance for vitamin D3 dosage.

Interactions

Several medications can interfere with Vitamin D3 absorption and metabolism, leading to deficiencies. These include:

• Magnesium-containing antacids
• Digoxin
• Thiazide diuretics
• Cholestyramine
• Phenytoin, Phenobarbital
• Orlistat
• Corticosteroids (e.g., Prednisolone) increase Vitamin D3 requirements.

Contraindications

Vitamin D3 should not be used in individuals with:

• Hypercalcemia
• Known hypersensitivity to Vitamin D3 or related substances
• Evidence of Vitamin D3 toxicity

Side Effects

Possible side effects, though rare, may include:

• Appetite loss, fatigue, nausea, vomiting
• Diarrhea, constipation, weight loss
• Increased urination, excessive sweating, headache, dizziness
• Elevated calcium and phosphate levels in blood and urine

Pregnancy & Lactation

Vitamin D3 is safe for use during pregnancy at doses up to 4,000 IU daily. The recommended intake for pregnant women is 400 IU daily, though higher doses may be necessary for those with Vitamin D3 deficiency. Always consult with a healthcare provider for personalized dosage recommendations.

Vitamin D3 and its metabolites are excreted in breast milk. While there is no evidence of overdose from breastfeeding, any additional Vitamin D3 supplementation for infants should be carefully managed by a healthcare provider.

Precautions & Warnings

Regular monitoring of plasma calcium levels is advised for individuals on high doses of Vitamin D3, especially in cases of renal impairment or pregnancy. Those on medications such as Digoxin or Thiazide diuretics should consult a healthcare provider before starting supplementation. Individuals with liver or kidney disease, hyperthyroidism, lymphoma, tuberculosis, or granulomatous diseases should seek professional advice prior to supplementation.

Special Populations: The safety and effectiveness of Vitamin D3 in children under 12 years have not been established.

Overdose Effects

Excessive intake of Vitamin D3 can lead to hypervitaminosis D, which may result in elevated calcium levels and other health issues.

Storage Conditions

Store below 30°C, away from light and moisture. Keep out of reach of children.