D-Rise 40000

Indications

D-Rise is vital for addressing Vitamin D3 deficiencies, especially in those with limited sunlight exposure or poor dietary intake. Essential for healthy bone and tooth development, it helps prevent rickets, osteomalacia, and osteoporosis. D-Rise also supports pregnant and breastfeeding women, aids in the prevention of pre-eclampsia, and boosts overall immunity.

Pharmacology

D-Rise contains Calcitriol, the active form of Vitamin D3. It binds to Vitamin D receptors (VDRs) throughout the body, crucial for increasing calcium absorption. As a fat-soluble vitamin with a half-life of approximately 50 days, it is absorbed in the small intestine, metabolized in the liver, and further processed in the kidneys. Excess Vitamin D3 is stored in fat and muscle, with elimination occurring through feces and urine.

Dosage & Administration

• Capsules:
  • Adults:
    • Deficiency: 40,000 IU weekly for 7 weeks; maintenance: 1,400-2,000 IU/day.
    • Prevention: 20,000 IU every 4 weeks; higher doses as needed.
    • Osteoporosis: 20,000 IU monthly.
  • Children (12-18 years):
    • Deficiency: 20,000 IU bi-weekly for 6 weeks.
    • Prevention: 20,000 IU every 6 weeks.
• Film-Coated Tablets: 1,000 IU (1-2 tablets) daily.
• Oroflash/Chewable Tablets: 1,000 IU to 2,000 IU daily.
• Syrup:
  • 0-1 year: 400 IU/day; 2,000 IU/day for 6 weeks if deficient.
  • >1 year: 600 IU/day; 2,000 IU/day for 6 weeks if deficient.
• Injection:
  • Infants (Vitamin D milk): 100,000 IU every 6 months.
  • Infants/Young Children (no Vitamin D milk): 200,000 IU every 6 months.
  • Adolescents: 200,000 IU every 6 months in winter.
  • Pregnancy: 100,000 IU from 6th or 7th month.
  • Elderly: 100,000 IU every 3 months.

Interactions

D-Rise may interact with medications that affect Vitamin D3 absorption, including Magnesium antacids, certain diuretics, and antiepileptics. Corticosteroids can increase Vitamin D3 requirements.

Contraindications

Avoid D-Rise in individuals with hypersensitivity to Vitamin D3 or those with hypercalcemia.

Side Effects

Potential side effects include nausea, headache, diarrhea, dyspepsia, dizziness, abdominal pain, and vomiting.

Pregnancy & Lactation

Safe for use during pregnancy at doses up to 4,000 IU. Follow medical advice for exact dosing. D-Rise and its metabolites are excreted in breast milk; consider this when prescribing additional Vitamin D3 to breastfeeding infants.

Precautions & Warnings

Monitor plasma-calcium levels in high doses, renal impairment, and during pregnancy. Consult healthcare providers if using Digoxin, Thiazide diuretics, or if you have liver or kidney disease.

Use in Special Populations

Safety for children under 12 has not been established.

Overdose Effects

Can cause hypervitaminosis D.

Therapeutic Class

Vitamin D preparations for bone health.

Storage Conditions

Store below 30°C, protected from light and moisture. Keep out of reach of children.