D-Rise 1000

Indications

Vitamin D3 deficiency can arise due to limited sunlight exposure or a diet lacking in Vitamin D3. This essential nutrient plays a crucial role in facilitating calcium and phosphate absorption, vital for maintaining healthy bones and teeth, and preventing conditions like rickets, osteomalacia, and osteoporosis. Additionally, adequate Vitamin D3 intake is essential during pregnancy and breastfeeding to reduce the risk of pre-eclampsia and support infant development. Vitamin D3 also supports immune system function.

Pharmacology

The active form of Vitamin D3, Calcitriol, functions by binding to Vitamin D receptors (VDRs) found in various body tissues. Vitamin D3, being fat-soluble, has a half-life of approximately 50 days. After absorption in the small intestine, it binds to specific globulins and undergoes metabolism in the liver to form 25-hydroxy Vitamin D3 (Calcidiol). Further hydroxylation in the kidneys produces 1,25-dihydroxy Vitamin D3 (Calcitriol), which enhances calcium absorption. Unused Vitamin D3 is stored in fat and muscle tissues and eliminated through feces and urine.

Dosage & Administration

• Capsule (Adults):
  • Treatment of Vitamin D3 deficiency: 40,000 IU once weekly for 7 weeks. Maintenance therapy ranges from 1,400-2,000 IU/day.
  • Prevention of Vitamin D3 deficiency: 20,000 IU every 4 weeks, with adjustments as needed.
  • Addition to osteoporosis therapy: 20,000 IU monthly.
• Capsule (Children 12-18 years):
  • Treatment of Vitamin D3 deficiency: 20,000 IU once every 2 weeks for 6 weeks.
  • Prevention of Vitamin D3 deficiency: 20,000 IU every 6 weeks.
• Film-coated tablet: 1,000 IU (1-2 tablets) daily, with food or within 1 hour after a meal.
• Oroflash or chewable tablets: 1,000-2,000 IU daily, taken with food.
• Syrup: Dosage varies by age and deficiency risk.

Interaction

Several medications can lead to Vitamin D3 deficiency by interfering with its absorption and metabolism. These include antacids containing magnesium, digoxin, thiazide diuretics, and corticosteroids like prednisolone.

Contraindications

Vitamin D3 should not be used in conditions associated with high calcium levels, hypersensitivity to Vitamin D3, or evidence of Vitamin D3 toxicity.

Side Effects

Rare side effects may include gastrointestinal symptoms, fatigue, and disturbances in calcium and phosphate levels.

Pregnancy & Lactation

Up to 4,000 IU of Vitamin D3 daily appears safe during pregnancy, although doses should be tailored to individual needs and monitored by healthcare providers.

Precautions & Warnings

Monitoring of calcium levels is advised for individuals receiving high doses of Vitamin D3, those with renal impairment, and during pregnancy or lactation. Consultation with a healthcare provider is recommended for individuals with specific medical conditions.

Use in Special Populations

The safety and efficacy of Vitamin D3 in children under 12 years old have not been established.

Overdose Effects

Excessive Vitamin D3 intake can result in hypervitaminosis D.

Therapeutic Class

Vitamin-D preparations that support bone health and overall well-being.

Storage Conditions

Store below 30°C, protected from light and moisture, and out of reach of children.