Cystosan 100

Indications

Cystosan is prescribed for relieving bladder pain or discomfort associated with interstitial cystitis.

Consult a registered physician before using this medication.

Pharmacology

Cystosan contains Pentosan Polysulfate Sodium, a polymer of xylose hydrogen sulfate, which binds to fibroblast growth factors (FGFs) and other heparin-binding growth factors. It works by interacting with the heparin-binding site of FGFR-1, inhibiting cell growth and tumorigenicity in specific cancer cells. This mechanism helps alleviate pain and discomfort related to bladder inflammation.

Dosage & Administration

• Recommended dose: 300 mg per day, divided into three 100 mg doses. Take orally with water, at least 1 hour before meals or 2 hours after meals.
• Reevaluation: Patients should be reassessed after 3 months. If no improvement is seen, treatment can be extended for another 3 months.
• Pediatric Use: Safety in children under 16 years has not been established.

Always follow your healthcare provider’s instructions.

Interactions

• Warfarin: No significant pharmacokinetic interaction between Cystosan and warfarin was observed, meaning INR levels remained consistent.

Contraindications

Do not use Cystosan if you are allergic to Pentosan Polysulfate Sodium or any related compounds.

Side Effects

Common side effects may include:

• Alopecia (4%)
• Diarrhea (4%)
• Nausea (4%)
• Headache (3%)
• Rash (3%)
• Dyspepsia (2%)
• Abdominal pain (2%)
• Liver function abnormalities (1%)
• Dizziness (1%)

Pregnancy & Lactation

• Pregnancy: Animal studies did not show harmful effects at certain doses. However, adequate human studies are lacking, so Cystosan should be used during pregnancy only if clearly needed.
• Breastfeeding: It is unknown whether Cystosan is excreted in breast milk. Use caution when administering this medication to nursing mothers.

Precautions & Warnings

• Anticoagulant Effects: Cystosan is a weak anticoagulant and can cause bleeding complications, including rectal hemorrhage, ecchymosis, epistaxis, and gum bleeding.
• Risk of Bleeding: Patients with coagulopathy or those on blood thinners should be closely monitored.
• Alopecia: Alopecia is a known side effect, often starting within 4 weeks of treatment. Most cases are limited to a small area on the scalp and resolve after discontinuation of treatment.

Therapeutic Class:
Other genito-urinary preparations

Storage Conditions

Store at temperatures below 30°C, away from light and moisture. Keep out of reach of children.