Contova

Indications

Patadin Eye Drops:
Patadin is indicated for managing the signs and symptoms of allergic conjunctivitis, such as itchy, watery, red, or swollen eyes and eyelids. It is also effective in conditions like vernal keratoconjunctivitis, vernal keratitis, blepharitis, blepharoconjunctivitis, and giant papillary conjunctivitis.

Contova Nasal Spray:
This H1 receptor antagonist provides relief from symptoms of seasonal allergic rhinitis in adults and children aged 6 years and older.

Contova Tablet:
Designed to treat allergic rhinitis (nasal swelling due to allergens like pollen and mold spores) and skin-related allergies, Contova tablets alleviate symptoms like rashes, swelling, hives, itching, sneezing, and nasal congestion.

Always use as directed by a registered healthcare professional.

Pharmacology

Olopatadine, an antihistamine, works by blocking histamine, which helps reduce allergy symptoms. It effectively addresses sneezing, itching, and nasal congestion caused by allergies.

• Mechanism of Action:
  Olopatadine stabilizes mast cells, preventing histamine release, and acts as a selective H1 receptor antagonist, reducing inflammatory mediators like prostaglandins and cytokines.
• Pharmacokinetics:
  • Absorption: Peak plasma concentrations occur 30 minutes to 1 hour after intranasal use.
  • Distribution: Olopatadine binds moderately to proteins (about 55%).
  • Metabolism: Minimal metabolism with six minor plasma metabolites.
  • Elimination: Half-life is 8–12 hours, mainly excreted via urine.

Dosage

Patadin Eye Drops:

• 0.1%: One drop in each affected eye twice daily (6-8 hour interval).
• 0.2%: One drop in each affected eye once daily.
• 0.7%: One drop in each affected eye once daily.

Contova Nasal Spray:

• Adults & Adolescents (12+ years): Two sprays per nostril, twice daily.
• Children (6–11 years): One spray per nostril, twice daily.

Contova Tablet:

• Adults: 5 mg twice daily, morning and evening.
• Children (7+ years): Same as adults.

Missed doses should not be doubled. Consult a doctor before discontinuing.

Administration Instructions

Using the Nasal Spray:

1. Shake gently and remove the dust cover.
2. Prime the spray until a fine mist appears.
3. Blow your nose to clear the nostrils.
4. Insert the nozzle into one nostril, tilt your head slightly forward, and spray while inhaling.
5. Exhale through your mouth and repeat for the other nostril.

Cleaning the Spray:
Clean the applicator weekly by washing it with warm water, drying naturally, and reassembling.

Avoid applying heat to dry the spray components.

Interactions

No significant drug interactions are anticipated, as olopatadine is primarily eliminated via renal excretion. Interactions related to P450 enzymes or plasma protein binding are unlikely.

Contraindications

Do not use if you are hypersensitive to any components of this product. Inform your doctor of any ongoing medications or health conditions before use.

Side Effects

Common side effects include headaches, blurred vision, dry eyes, or nasal discomfort. Rarely, allergic reactions or systemic effects like nausea and fatigue may occur.

Use During Pregnancy & Lactation

While animal studies show no teratogenic effects, adequate studies in pregnant women are lacking. Use only if benefits outweigh risks. Olopatadine’s excretion in human breast milk is unknown, so caution is advised for nursing mothers.

Precautions

• Avoid wearing contact lenses when experiencing red or irritated eyes.
• Do not use Patadin Eye Drops for contact lens-related irritation.
• Re-prime the nasal spray if unused for over seven days.
• Follow your doctor’s prescription closely.

Overdose

In case of suspected overdose, seek immediate medical assistance.

Storage

Store at room temperature, away from direct light. Use eye drops within one month of opening.