Contilex TS

Indications

This supplement is recommended for treating osteoarthritis affecting various joints such as the knee, hip, spine, hand, and others. It also serves as a beneficial dietary supplement for conditions like rheumatoid arthritis, sports injuries, migraines, skin issues (e.g., psoriasis), vascular problems (e.g., atherosclerosis), kidney stones, and inflammatory bowel diseases (e.g., ulcerative colitis, leaky gut syndrome).

Pharmacology

Glucosamine, a natural amino-sugar produced by the body and found in certain foods, is essential for synthesizing glycosaminoglycans (GAGs) like Hyaluronic Acid, Keratan Sulfate, and Chondroitin Sulfate. These compounds form proteoglycans, crucial for the structure of joint cartilage and other connective tissues. Supplementation with Glucosamine Sulfate supports cartilage production and repair by increasing Glucosamine levels in the body. Additionally, it activates chondrocytes within cartilage, promoting GAG and proteoglycan synthesis.

Chondroitin Sulfate, another glycosaminoglycan found in connective tissue, acts similarly to Glucosamine Sulfate by supporting proteoglycan formation and protecting healthy cartilage from premature degradation.

Combining Glucosamine with Chondroitin Sulfate demonstrates a synergistic effect, effectively treating severe osteoarthritis symptoms and modifying disease progression. Studies indicate comparable pain relief to NSAIDs with improved tolerability and clinical compliance. It also aids in the repair of musculoskeletal soft tissue injuries such as tendon or ligament strains.

Dosage & Administration

Dosage recommendations vary based on body weight and response to treatment. Typical daily dosages range from 1000 mg Glucosamine Sulfate & 800 mg Chondroitin Sulfate for individuals under 54 kg, to 2000 mg Glucosamine Sulfate & 1600 mg Chondroitin Sulfate for those over 91 kg. Dosages may be adjusted after 60 days for optimal results and cost-effectiveness.

Interaction

Glucosamine and Chondroitin have not shown significant interactions with antibiotics, antidepressants, antihypertensives, nitrates, antiarrhythmics, anxiolytics, hypoglycemic agents, antisecretives, or antiasthmatics. Chondroitin may enhance the effects of anticoagulants like Warfarin and Heparin.

Contraindications

There are no known contraindications, except for individuals with proven hypersensitivity (e.g., shellfish or sulfur allergies) to Glucosamine and Chondroitin.

Side Effects

Safety studies indicate rare and mild side effects, such as reversible intestinal flatulence, which are comparable to placebo effects.

Pregnancy & Lactation

Pregnant or lactating women should avoid supplementation with Glucosamine Sulfate and Chondroitin Sulfate due to insufficient studies on their effects on fetal development.

Precautions & Warnings

Patients with Diabetes Mellitus should monitor blood glucose levels regularly when taking Glucosamine. While no specific studies have been conducted in patients with renal or hepatic insufficiency, caution is advised, and medical supervision is recommended for severe cases.

Therapeutic Class

Stimulation of Cartilage Formation

Storage Conditions

Store in a cool, dry place away from light.