Indications
Comprid XR is a medication designed to lower blood sugar levels and is classified as an oral antidiabetic drug within the sulphonylurea group. It is primarily used to manage type 2 diabetes Mellitus in adults when conventional methods such as diet, exercise, and weight loss fail to adequately control blood sugar levels.
Pharmacology
Gliclazide, the active ingredient in Comprid XR, belongs to the second generation of sulfonylurea drugs. It exhibits hypoglycaemic properties by stimulating insulin release from pancreatic β-cells. This mechanism involves facilitating Ca+2 transport across β-cell membranes and reducing hepatic glucose output.
Dosage & Administration
For the film-coated tablet formulation, the initial daily dose typically ranges from 40 to 80 mg, with the possibility of increasing up to 320 mg daily in divided doses as required. It is recommended to take the medication before meals. Dosage adjustments may be necessary based on individual response and changes in external factors such as weight reduction or lifestyle modifications.
In the case of the modified release preparation, the recommended daily dose ranges from one to four tablets (maximum 120 mg) to be taken as a single intake during breakfast. The dosage regimen should be determined by a healthcare professional depending on blood sugar levels and treatment response. It’s crucial to swallow the tablet(s) whole with water and follow with a meal.
In combination therapy with other antidiabetic agents, the dosage of each medication should be tailored to individual patient needs. Prompt medical attention is advised if blood sugar levels remain high despite adherence to the prescribed regimen.
If a dose is missed, it should be taken as soon as remembered, unless it’s almost time for the next scheduled dose. Doubling up on doses should be avoided.
Before discontinuing Comprid XR, consultation with a healthcare provider is essential due to the lifelong nature of diabetes treatment. Abrupt cessation may lead to elevated blood sugar levels and increase the risk of complications.
Interaction
Patients should inform their healthcare provider about any concurrent medications, including recent use, to mitigate potential interactions with Comprid XR. Certain medications can potentiate or attenuate its blood sugar-lowering effects, necessitating careful monitoring and dose adjustments.
Precautions & Warnings
Prior consultation with a healthcare provider is recommended before initiating Comprid XR therapy. Patients should adhere to prescribed treatment plans, including dietary recommendations, exercise regimens, and weight management strategies. Regular monitoring of blood sugar levels and glycated hemoglobin levels is imperative, especially during the initial phases of treatment.
Hypoglycaemia may occur under various circumstances, including irregular meals, fasting, malnutrition, changes in diet or physical activity, alcohol consumption, or concurrent medication use. Symptoms range from mild to severe and require prompt intervention with appropriate sugar intake. Patients should carry a readily accessible source of sugar for emergency situations.
Additionally, awareness of hyperglycaemic symptoms is essential, particularly if blood sugar levels remain inadequately controlled. Stressful situations, concomitant medication use, or St. John’s Wort preparations can exacerbate hyperglycaemia and necessitate vigilant monitoring.
Individuals with a history of glucose-6-phosphate dehydrogenase deficiency should exercise caution when using Comprid XR, as it may lead to haemolytic anaemia.
Comprid XR is contraindicated in pregnant and breastfeeding women, individuals with insulin-dependent diabetes (type 1), severe kidney or liver disease, and those allergic to sulfonylureas or related compounds.
Side Effects
Common side effects of Comprid XR include hypoglycaemia, liver disorders, skin reactions, blood disorders, digestive disturbances, and eye disorders. Patients experiencing severe or prolonged hypoglycaemia should seek immediate medical attention. Other adverse reactions may necessitate discontinuation of treatment and consultation with a healthcare provider.
Pregnancy & Lactation
Due to safety concerns, Comprid XR is not recommended during pregnancy or breastfeeding. Women of childbearing age should consult their healthcare provider for alternative treatment options.
Storage Conditions
Store Comprid XR tablets below 30°C, away from children’s reach and sight. Avoid using expired medication, and dispose of unused tablets according to pharmacist instructions to minimize environmental impact.
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