Compiron Pediatric Drops

Indications

Compiron 30 ml is prescribed for the treatment of latent iron deficiency and iron deficiency anemia, including macrocytic anemia, nutritional anemia in infants, anemia resulting from excessive blood loss, and anemia related to infections or malignant conditions. It is also indicated for the prevention and treatment of iron deficiency anemia before, during, and after pregnancy, as well as during breastfeeding. Additionally, Compiron 30 ml can be used prophylactically to meet the recommended daily dietary iron requirements (RDA).

Therapeutic Class

Oral Iron Supplements

Pharmacology

Compiron 30 ml is formulated as a polysaccharide-iron complex, offering an innovative solution for managing iron deficiency anemia. Iron, a vital element for the body, plays a key role in hemoglobin production and the oxidative processes of tissues. This formula contains non-ionic ferric iron in a stable polymaltose complex, which allows controlled absorption at the mucosal surface of cells. Its non-ionic nature prevents the release of harmful free radicals, avoiding the toxic side effects commonly associated with traditional ionic iron salts. Furthermore, Compiron 30 ml does not interact with food or other medications, ensuring superior bioavailability compared to ferrous salts. This ensures efficient utilization of iron for hemoglobin and myoglobin synthesis.

Dosage and Administration

Dosage and duration of treatment depend on the severity of iron deficiency and should follow a physician’s guidance.

• Adults: 10 ml once or twice daily
• Children (6-12 years): 10 ml once daily
• Children (2-6 years): 5 ml daily
• Premature infants and infants: 3.33 mg of elemental iron per kg of body weight

Interactions with Other Medications

Compiron 30 ml has shown minimal interactions with other substances. Due to its iron being bound in a complex form, it is unlikely to undergo ionic interactions with food (such as phytates, oxalates, or tannins) or other medications like tetracyclines and antacids.

Contraindications

Compiron 30 ml should not be used in cases where there is a risk of iron overload, such as in patients with hemochromatosis, thalassemia, or hemosiderosis. It is also contraindicated for individuals with known hypersensitivity to iron or any other ingredient in the formulation.

Potential Side Effects

While Compiron 30 ml is generally well-tolerated, some individuals may experience mild side effects commonly associated with oral iron supplements, including nausea, vomiting, constipation, or diarrhea.

Use During Pregnancy & Lactation

Compiron 30 ml is safe and recommended for use during pregnancy and lactation under medical supervision.

Precautions & Warnings

In cases of overdose, symptoms such as epigastric pain, diarrhea, vomiting, and even metabolic acidosis, convulsions, or coma may occur after an apparent recovery. Immediate medical intervention is essential. Initial treatment may include the use of an emetic, followed by gastric lavage with sodium bicarbonate and oral administration of desferrioxamine to bind excess iron.

Overdose Management

Symptoms of iron overdose may include epigastric pain, diarrhea, vomiting, and in severe cases, metabolic acidosis, convulsions, or coma. In such events, immediate medical attention is required, starting with the administration of an emetic followed by gastric lavage and supportive care.

Storage Guidelines

Store below 30°C, away from moisture and light. Keep out of the reach of children.

Drug Class

Oral Iron Preparations

Mechanism of Action

Compiron 30 ml’s polysaccharide-iron complex ensures optimal absorption and usage of iron within the body. Iron is necessary for hemoglobin production and other vital oxidative processes. The complex contains stable non-ionic ferric iron, which is gradually absorbed as it interacts with the mucosal cells, without releasing harmful free radicals. It also ensures no interaction with food or other medications, resulting in superior bioavailability compared to traditional ferrous salts. This leads to faster and more efficient utilization of iron in hemoglobin and myoglobin synthesis.

Use During Pregnancy

The administration of iron supplements in the first trimester of pregnancy requires a careful risk-benefit assessment and should only be used when absolutely necessary. During the later stages of pregnancy, iron supplementation may be indicated but should only be taken under the supervision of a healthcare provider. Iron is present in breast milk, though typically at clinically insignificant levels.