Climycin

Indications

Climycin is a trusted remedy effective against various infections caused by susceptible anaerobic bacteria and gram-positive bacteria such as Streptococci, Staphylococci, and Pneumococci. It’s indicated for treating upper and lower respiratory infections, skin and soft tissue infections, bone and joint infections, pelvic infections, intra-abdominal infections, septicemia, endocarditis, and dental infections. Additionally, it serves as an alternative therapy in combination with quinine or amodiaquine for multi-drug resistant Plasmodium falciporum infection.

Description

Climycin, a lincosamide antibiotic, is derived from lincomycin and is proven effective against susceptible microorganisms. It targets a wide range of bacteria, including aerobic gram-positive cocci like Staphylococcus aureus and Streptococci, as well as anaerobic bacteria like Bacteroides and Fusobacterium species.

Dosage & Administration

• For Clindamycin Capsules (Adults):
  • For serious infections: 150-300 mg every six hours.
  • For more severe infections: 300-450 mg every six hours.
• For Clindamycin Powder for oral solution:
  • Dosage ranges based on severity and patient weight, divided into 3 or 4 equal doses.
• For Clindamycin IV/IM Injection:
  • Dosage varies for adults, neonates, and pediatric patients based on infection severity.

Interaction

Climycin may enhance the action of neuromuscular blocking agents and should be used cautiously with them. Concurrent use with erythromycin should be avoided due to potential antagonism.

Contraindications

Patients with known sensitivity to clindamycin or its ingredients should not use Climycin.

Side Effects

Adverse effects may include abdominal pain, esophagitis, nausea, vomiting, diarrhea, pruritus, skin rashes, and urticaria.

Pregnancy & Lactation

Climycin is classified as Pregnancy Category B and should be used during pregnancy only if clearly needed. It can pass into breast milk, so caution is advised in nursing mothers.

Precautions & Warnings

Climycin should be prescribed cautiously in patients with a history of gastrointestinal disease, particularly colitis.

Use in Special Populations

Monitoring organ system functions is advisable when administering Climycin to newborns and infants. Dose adjustment is not necessary for geriatric patients.

Overdose Effects

Overdosage with Climycin is rare but may result in adverse reactions similar to normal doses. Gastric lavage is recommended for treatment.

Therapeutic Class

Climycin belongs to the macrolides class of antibiotics.

Reconstitution & Storage

Follow specific directions for reconstitution and storage provided with Climycin products, keeping them below 30°C, away from light and moisture, and out of reach of children.

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