Cerox CV

Indications

Cerox CV is used to treat infections caused by bacteria that are susceptible to the drug. These include:

• Pharyngitis/Tonsillitis caused by Streptococcus pyogenes.
• Acute Bacterial Otitis Media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis (beta-lactamase-producing strains), or Streptococcus pyogenes.
• Acute Bacterial Maxillary Sinusitis caused by Streptococcus pneumoniae or Haemophilus influenzae (non beta-lactamase-producing strains).
• Lower Respiratory Tract Infections, including pneumonia, caused by Streptococcus pneumoniae, Haemophilus influenzae (including beta-lactamase-producing strains), Klebsiella spp., Staphylococcus aureus (both penicillinase-producing and non-penicillinase-producing strains), Streptococcus pyogenes, and E. coli.
• Acute Bacterial Exacerbation of Chronic Bronchitis and Secondary Bacterial Infections of acute bronchitis caused by Streptococcus pneumoniae, Haemophilus influenzae (beta-lactamase negative strains), or Haemophilus parainfluenzae (beta-lactamase negative strains).
• Uncomplicated Skin and Skin-Structure Infections caused by Staphylococcus aureus (including beta-lactamase-producing strains) or Streptococcus pyogenes.
• Uncomplicated Urinary Tract Infections caused by E. coli or Klebsiella pneumoniae.
• Bone and Joint Infections caused by Staphylococcus aureus (penicillinase- and non-penicillinase-producing strains).
• Uncomplicated Gonorrhoea caused by penicillinase-producing and non-penicillinase-producing strains of Neisseria gonorrhoeae.
• Early Lyme Disease (erythema migrans) caused by Borrelia burgdorferi.
• Septicemia caused by Staphylococcus aureus, Streptococcus pneumoniae, E. coli, Haemophilus influenzae (including ampicillin-resistant strains), and Klebsiella spp.
• Meningitis caused by Streptococcus pneumoniae, Haemophilus influenzae (including ampicillin-resistant strains), Neisseria meningitidis, and Staphylococcus aureus (penicillinase- and non-penicillinase-producing strains).
• Switch therapy (Injectable to oral).

Always follow your healthcare provider’s guidance.

Pharmacology

Cerox CV combines Cefuroxime, a potent second-generation cephalosporin antibiotic, with Clavulanic Acid, a beta-lactamase inhibitor.

• Cefuroxime works by disrupting bacterial cell wall synthesis, making it effective against a wide range of Gram-positive and Gram-negative bacteria, including those that produce beta-lactamase.
• Clavulanic Acid inactivates beta-lactamase enzymes, enhancing Cefuroxime’s ability to fight resistant bacteria.

This combination ensures effective treatment against a variety of bacterial infections, including those resistant to other antibiotics.

Dosage & Administration

For Adolescents and Adults (13 years and older):

• Pharyngitis/Tonsillitis: 250 mg twice daily for 5-10 days
• Acute Bacterial Maxillary Sinusitis: 250 mg twice daily for 10 days
• Acute Bacterial Exacerbation of Chronic Bronchitis: 250-500 mg twice daily for 10 days
• Secondary Bacterial Infections of Acute Bronchitis: 250-500 mg twice daily for 5-10 days
• Uncomplicated Skin Infections: 250-500 mg twice daily for 10 days
• Uncomplicated UTI: 250 mg twice daily for 7-10 days
• Uncomplicated Gonorrhoea: 1000 mg as a single dose
• Community Acquired Pneumonia: 250-500 mg twice daily for 5-10 days
• MDR Typhoid Fever: 500 mg twice daily for 10-14 days
• Early Lyme Disease: 500 mg twice daily for 20 days

For Paediatric Patients (3 months to 12 years):

• Pharyngitis/Tonsillitis: 20 mg/kg/day twice daily for 5-10 days
• Acute Otitis Media: 30 mg/kg/day twice daily for 10 days
• Acute Bacterial Maxillary Sinusitis: 30 mg/kg/day twice daily for 10 days
• Impetigo: 30 mg/kg/day twice daily for 10 days

Cerox CV can be taken with or without food.

Consult with a registered healthcare provider before use.

Interaction

• Co-administration with probenecid increases the serum concentration of Cefuroxime.
• Antacids or drugs that lower gastric acidity may reduce the bioavailability of Cefuroxime.

Contraindications

Cerox CV should not be used in individuals who are allergic to cephalosporins or those with Pseudomembranous Colitis.

Side Effects

• Generally well-tolerated, but may cause mild side effects like nausea, vomiting, diarrhea, or abdominal discomfort.
• Prolonged use can lead to overgrowth of non-susceptible organisms.
• Rare effects include renal dysfunction, anaphylaxis, angioedema, skin rash, and serum sickness.

Pregnancy & Lactation

• Cefuroxime-Clavulanic Acid is safe to use in the later stages of pregnancy, especially for treating urinary tract infections and other bacterial infections.
• The medication is excreted in breast milk in small quantities; use with caution during breastfeeding.

Precautions & Warnings

• Exercise caution when administering Cerox CV to patients taking potent diuretics or those with a history of colitis.

Therapeutic Class

• Second-generation Cephalosporins, Vaccines, Anti-sera, and Immunoglobulin.

Storage Conditions

• Store in a cool, dry place (below 30°C), away from light and moisture.
• Keep out of reach of children.