Ceftoril PFS

Indications

Ceftoril is used for treating mild-to-moderate infections caused by specific bacteria. It is effective in:

• Acute Bacterial Exacerbations of Chronic Bronchitis: Caused by Haemophilus influenzae, Moraxella catarrhalis, or Streptococcus pneumoniae (penicillin-susceptible strains).
• Acute Bacterial Otitis Media: Due to Haemophilus influenzae, Moraxella catarrhalis, or Streptococcus pyogenes.
• Pharyngitis and Tonsillitis: Caused by Streptococcus pyogenes.

Pharmacology

Ceftoril, a semi-synthetic cephalosporin antibiotic, is effective in treating infections by binding to bacterial cell wall proteins, inhibiting cell-wall synthesis, and exerting bactericidal effects.

Dosage & Administration

• Otitis Media:
  • Adults: 400 mg orally once daily for 10 days.
  • Children (>6 months): 9 mg/kg/day (max 400 mg) orally once daily for 10 days.
• Tonsillitis/Pharyngitis:
  • Adults: 400 mg orally once daily for 10 days.
  • Children (>6 months): 9 mg/kg/day (max 400 mg) orally once daily for 10 days.
• Bronchitis:
  • Adults: 400 mg orally once daily for 10 days.
  • Children (>12 years): 400 mg orally once daily for 10 days.
• Cystitis:
  • Adults: 400 mg orally once daily for 7 days.
  • Children (>12 years): 400 mg orally once daily for 7 days.
• Pneumonia:
  • Adults: 200 mg orally every 12 hours for 7 to 14 days.
  • Children (>12 years): 200 mg orally every 12 hours for 7 to 14 days.
• Sinusitis:
  • Adults: 400 mg orally once daily for 10 to 14 days.
  • Children (>12 years): 400 mg orally once daily for 10 to 14 days.
• Urinary Tract Infection:
  • Adults: 400 mg orally once daily for 10 days.
  • Children (>6 months): 9 mg/kg/day (max 400 mg) orally once daily for 10 days.

Follow your healthcare provider’s instructions for proper use.

Interaction

Ceftoril’s pharmacokinetics are unaffected by theophylline and antacids, but ranitidine increases its Cmax and AUC.

Contraindications

Do not use Ceftoril in patients with known allergies to cephalosporins. It is not recommended for managing premature labor or threatened abortion during early pregnancy.

Mode of Action

Ceftoril, a beta-lactam antibiotic, works by targeting bacterial cell wall synthesis, leading to bacterial cell death.

Precautions

Monitor for the development of resistant organisms with prolonged use. Adjust dosage in patients with renal insufficiency and use with caution in those with a history of gastrointestinal issues, particularly colitis.

Use in Special Populations

• Renal Impairment:
  • CrCl 5 to 29 ml/min: 100 mg orally once daily.
  • CrCl 30 to 49 ml/min: 200 mg orally once daily.
• Hepatic Impairment: No dosage adjustment needed.

Therapeutic Class

Third-generation Cephalosporins.

Reconstitution

1. Pour the entire contents of the purified water bottle into the large bottle with granules.
2. Shake well for at least one minute.
3. Use a measuring cup or dropper for accurate dosing.

The reconstituted suspension should be used within 14 days if stored in the refrigerator. Shake well before each use.

Storage Conditions

Store below 25°C, protected from light and moisture. The reconstituted suspension is stable for 14 days when refrigerated between 2° to 8°C. Keep out of reach of children.