Ceftiben

Indications

Ceftiben serves as a remedy for mild-to-moderate infections instigated by susceptible strains of specific microorganisms. It effectively tackles various conditions, including acute bacterial exacerbations of chronic bronchitis, acute bacterial otitis media, and pharyngitis and tonsillitis.

Pharmacology

As the dihydrate salt of Ceftibuten, Ceftiben acts as a semi-synthetic cephalosporin antibiotic, binding to essential target proteins within bacterial cell walls. This interaction inhibits cell-wall synthesis, ultimately exerting bactericidal action.

Dosage & Administration

Tailored to different infections, Ceftiben dosages vary for adults and pediatric patients, ensuring optimal treatment duration and efficacy. From bronchitis to urinary tract infections, precise dosing guidelines are provided for each condition.

Interaction

While theophylline and antacids pose no significant alterations to Ceftiben’s pharmacokinetic profile, ranitidine can increase its Cmax and AUC.

Contraindications

Patients with known cephalosporin antibiotic allergies should avoid Ceftiben.

Side Effects

Common side effects include nausea, headache, diarrhea, dyspepsia, dizziness, abdominal pain, and vomiting.

Pregnancy & Lactation

Considered Pregnancy Category B, Ceftiben usage during pregnancy should be carefully weighed against potential risks. Its excretion in human milk remains unknown, necessitating caution during lactation.

Precautions & Warnings

Prolonged treatment may lead to resistant organism emergence. Adjustment of Ceftiben dosage may be necessary for patients with renal insufficiency or gastrointestinal diseases.

Use in Special Populations

Dosing adjustments may be required for patients with renal impairment, while no adjustments are necessary for those with hepatic impairment.

Therapeutic Class

Ceftiben belongs to the class of third-generation cephalosporins, known for their broad-spectrum activity against bacteria.

Reconstitution

Detailed instructions are provided for reconstituting Ceftiben suspension, ensuring proper preparation and administration.

Storage Conditions

Ceftiben should be stored below 25°C, shielded from light and moisture. Once reconstituted, the suspension remains usable for up to 14 days when refrigerated, ensuring potency and efficacy.

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