Cefotil Plus 500
60.00৳ Pcs
- Unlock the power of Cefotil Plus, a potent antibiotic blend
- Formulated with Cefuroxime and Clavulanic acid for comprehensive bacterial infection treatment
- Targeting a range of conditions including pharyngitis, skin infections, and more
- Precise dosages tailored for both adults and pediatric patients
- Comprehensive precautions and storage guidelines ensure optimal efficacy
Brand |
Square Pharmaceuticals PLC |
---|---|
Generics |
Cefuroxime Axetil + Clavulanic Acid |
Indica
- Unlock the power of Cefotil Plus, a potent antibiotic blend
- Formulated with Cefuroxime and Clavulanic acid for comprehensive bacterial infection treatment
- Targeting a range of conditions including pharyngitis, skin infections, and more
- Precise dosages tailored for both adults and pediatric patients
- Comprehensive precautions and storage guidelines ensure optimal efficacy
tions
Cefotil Plus serves as a potent remedy for infections instigated by susceptible bacteria. It effectively tackles various conditions including:
- Pharyngitis/Tonsillitis caused by Streptococcus pyogenes.
- Acute Bacterial Otitis Media triggered by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis (including beta-lactamase producing strains), or Streptococcus pyogenes.
- Acute bacterial maxillary sinusitis initiated by Streptococcus pneumoniae or Haemophilus influenzae (non-beta-lactamase producing strains).
- Lower respiratory tract infections such as pneumonia, caused by Streptococcus pneumoniae, Haemophilus influenzae (including beta-lactamase-producing strains), Klebsiella spp., Staphylococcus aureus (penicillinase- and non-penicillinase-producing strains), Streptococcus pyogenes, and E. coli.
- Acute bacterial exacerbation of chronic bronchitis and secondary bacterial infections of acute bronchitis provoked by Streptococcus pneumoniae, Haemophilus influenzae (beta-lactamase negative strains), or Haemophilus parainfluenzae (beta-lactamase negative strains).
- Uncomplicated skin and skin-structure infections caused by Staphylococcus aureus (including beta-lactamase producing strains) or Streptococcus pyogenes.
- Uncomplicated urinary tract infections triggered by E. coli or Klebsiella pneumoniae.
- Bone and Joint Infections induced by Staphylococcus aureus (penicillinase- and non-penicillinase-producing strains).
- Uncomplicated Gonorrhoea caused by penicillinase-producing and non-penicillinase producing strains of Neisseria gonorrhoeae.
- Early Lyme Disease (erythema migrans) initiated by Borrelia burgdorferi.
- Septicemia provoked by Staphylococcus aureus, Streptococcus pneumoniae, E. coli, Haemophilus influenzae (including ampicillin-resistant strains), and Klebsiella spp.
- Meningitis caused by Streptococcus pneumoniae, Haemophilus influenzae (including ampicillin-resistant strains), Neisseria meningitidis, and Staphylococcus aureus (penicillinase and non-penicillinase producing strains).
- Switch therapy from injectable to oral form.
Pharmacology
Cefuroxime, a potent bactericidal second-generation cephalosporin antibiotic, demonstrates activity against a broad spectrum of Gram-positive and Gram-negative susceptible organisms, including many beta-lactamase producing strains. It operates by impeding bacterial cell wall synthesis through interference with the transpeptidation process.
Clavulanic acid, derived naturally and acting as a beta-lactamase inhibitor produced by Streptomyces clavuligerus, shares structural similarities with beta-lactam antibiotics. It irreversibly binds to beta-lactamase enzymes, inactivating them and safeguarding Cefuroxime from degradation by beta-lactamase enzymes, thus offering a viable solution for treating bacterial infections caused by beta-lactam-resistant bacteria.
Dosage & Administration
For adolescents and adults (13 years and older):
- Pharyngitis/tonsillitis: 250 mg twice daily for 5-10 days
- Acute bacterial maxillary sinusitis: 250 mg twice daily for 10 days
- Acute bacterial exacerbation of chronic bronchitis: 250-500 mg twice daily for 10 days
- Secondary bacterial infections of acute bronchitis: 250-500 mg twice daily for 5-10 days
- Uncomplicated skin and skin structure infections: 250-500 mg twice daily for 10 days
- Uncomplicated urinary tract infections: 250 mg twice daily for 7-10 days
- Uncomplicated Gonorrhoea: 1000 mg twice daily as a single dose
- Community-acquired pneumonia: 250-500 mg twice daily for 5-10 days
- MDR Typhoid Fever: 500 mg twice daily for 10-14 days
- Early Lyme disease: 500 mg twice daily for 20 days
For paediatric patients (3 months to 12 years):
- Pharyngitis/tonsillitis: 20 mg/kg/day twice daily for 5-10 days
- Acute otitis media: 30 mg/kg/day twice daily for 10 days
- Acute bacterial maxillary sinusitis: 30 mg/kg/day twice daily for 10 days
- Impetigo: 30 mg/kg/day twice daily for 10 days
Cefuroxime-Clavulanic Acid tablet may be taken without regard to food.
Interaction
Simultaneous administration of probenecid with Cefuroxime-Clavulanic Acid amplifies the area under the serum concentration versus time curve by 50%. Drugs that reduce gastric acidity may lead to a lower bioavailability of Cefuroxime and may tend to counteract the effect of postprandial absorption.
Contraindications
Cefuroxime-Clavulanic Acid is contraindicated in patients with a known allergy to cephalosporin and in patients with Pseudomembranous Colitis.
Side Effects
Cefuroxime-Clavulanic Acid is generally well tolerated. However, some side effects such as nausea, vomiting, diarrhea, abdominal discomfort or pain may occur. Prolonged administration of Cefuroxime and Clavulanic acid combination may result in overgrowth of nonsusceptible microorganisms. Rarely (<0.2%), renal dysfunction, anaphylaxis, angioedema, pruritis, rash, and serum sickness-like urticaria may manifest.
Pregnancy & Lactation
While all antibiotics should be avoided in the first trimester if possible, Cefuroxime-Clavulanic Acid can be safely used in later pregnancy to treat urinary and other infections. Cefuroxime-Clavulanic Acid is excreted into breast milk in small quantities. However, the potential for sensitizing the infant should be considered.
Precautions & Warnings
Cefuroxime should be administered with caution to patients receiving concurrent treatment with potent diuretics and those with a history of colitis.
Therapeutic Class
Second-generation Cephalosporins
Storage Conditions
Store in a cool, dry place (below 30°C), away from light and moisture. Keep out of the reach of children.
Common Questions about Cefotil Plus 500 mg Tablet
Here are some frequently asked questions about Cefotil Plus 500 mg Tablet:
- What is Cefotil Plus 500 mg Tablet?
- What is Cefotil Plus 500 mg Tablet used for?
- How long does it take for Cefotil Plus 500 mg Tablet to take effect?
- How long do the effects of this medicine last?
- Is Cefotil Plus 500 mg Tablet safe to consume alcohol while taking this medicine?
- Is Cefotil Plus 500 mg Tablet a habit-forming medicine?
- Can this medicine be taken during pregnancy?
- Can Cefotil Plus 500 mg Tablet be taken while breastfeeding?
Quick Tips
Here are some quick tips for using Cefotil Plus 500 mg Tablet:
- You have been prescribed Cefotil Plus 500 mg Tablet to treat bacterial infections, even if they have developed resistance.
- Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may cause the infection to return and become harder to treat.
- Take it with food to avoid an upset stomach.
- Diarrhea may occur as a side effect. Taking probiotics may help. Consult your doctor if you notice bloody stools or develop abdominal cramps.
- Stop taking Cefotil Plus 500 mg Tablet and inform your doctor immediately if you develop an itchy rash, swelling of the face, throat, or tongue, or breathing difficulties while taking it.
- Do not use leftover medicine for treating any infection in the future. Always consult your doctor before taking any antibiotic.
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