Cef-3 DS 400

Indications

• Cef-3, an orally active cephalosporin antibiotic, targets a wide range of bacterial infections, both Gram-positive and Gram-negative, making it ideal for various acute conditions.
• Effective in treating upper respiratory tract infections (URTI) like otitis media and resistant URTIs, along with lower respiratory tract infections such as bronchitis, it’s a versatile solution for common bacterial ailments.
• Its efficacy extends to urinary tract infections (UTIs) like cystitis and pyelonephritis, with demonstrated effectiveness against common pathogens, including Streptococcus pneumoniae and Escherichia coli.

Pharmacology

• Cefixime, the active ingredient, is a third-generation cephalosporin antibiotic known for its broad-spectrum bactericidal action against both Gram-positive and Gram-negative bacteria.
• It works by inhibiting bacterial cell wall synthesis, offering stability against beta-lactamase enzymes, making it effective against organisms resistant to other antibiotics.

Dosage & Administration

• Suitable for adults and children over 10 years, the dosage ranges from 200-400 mg daily, adjusted based on infection severity.
• For children, the dose is calculated based on weight, with guidelines provided for different age groups.
• Renal impairment considerations are crucial, with dosage adjustments necessary for severe cases.
• Food intake doesn’t significantly affect absorption, and the standard treatment duration is 7 days, extendable up to 14 days if needed.

Interaction

• Care should be taken in patients on anticoagulant therapy due to potential increases in prothrombin times.

Contraindications

• Avoid in patients with known hypersensitivity to cephalosporin antibiotics.

Side Effects

• Generally well-tolerated, common side effects include gastrointestinal disturbances like diarrhea and nausea.
• Other rare side effects include headache, allergic reactions, and hematological abnormalities.

Pregnancy & Lactation

• Caution advised during pregnancy and lactation, with usage recommended only if clearly needed.

Precautions & Warnings

• Use with caution in patients with known hypersensitivity to other drugs and in those with impaired renal function.
• Avoid in penicillin-sensitive patients due to potential cross-allergenicity.
• Broad-spectrum antibiotic usage may disrupt normal colon flora, leading to antibiotic-associated diarrhea.

Overdose Effects

• Gastric lavage may be indicated in overdose situations, with no specific antidote available.
• Limited removal via dialysis is observed, with adverse reactions comparable to recommended doses.

Therapeutic Class

• Third-generation cephalosporins, renowned for their broad-spectrum activity.

Storage Conditions

• Store below 30°C, away from light and moisture, ensuring it’s out of children’s reach.

Molecular Formula :	C16H15N5O7S2
Chemical Structure :