Candela 1% Shampoo

Indications

Ciclopirox Olamine Shampoo is recommended for addressing seborrheic dermatitis, dandruff, and inflammation of the scalp.
Use as directed by a registered healthcare professional.

Pharmacology

Ciclopirox Olamine is a synthetic antifungal agent with broad-spectrum efficacy, effectively targeting pathogenic dermatophytes, yeasts, and Malassezia furfur. It demonstrates fungicidal properties in vitro against several isolates, including Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis, and Candida albicans. The primary mode of action for Ciclopirox Olamine has been extensively studied in Candida albicans, where it appears to inhibit fungal cell growth or induce cell death by depleting essential substrates and ions in vitro, likely by blocking their absorption from the environment. In addition to its antifungal capabilities, Ciclopirox exhibits antibacterial activity against a range of both Gram-positive and Gram-negative bacteria. Its anti-inflammatory properties have been confirmed in human polymorphonuclear cells, where it reduces the synthesis of prostaglandins and leukotrienes, and may inhibit the activity of 5-lipoxygenase and cyclooxygenase.

Dosage & Administration

To use, wet the hair and apply approximately 1 teaspoon (5 ml) of Ciclopirox Olamine Shampoo directly onto the scalp. For longer hair, up to 2 teaspoons (10 ml) can be used. Lather the shampoo and leave it on the hair and scalp for 3 minutes; a timer can assist with this. Avoid contact with eyes. For optimal results, apply twice a week for 4 weeks, ensuring at least 3 days between each application.
Use as directed by a registered healthcare professional.

Contraindications

This shampoo should not be used by individuals who have demonstrated hypersensitivity to any of its ingredients.

Side Effects

Ciclopirox Olamine Shampoo is generally well tolerated, with a low incidence of adverse reactions reported during clinical studies.

Pregnancy & Lactation

Classified as pregnancy category B, it is unclear whether Ciclopirox Olamine is excreted in human milk. Caution is advised when administering this shampoo to nursing women due to the potential for drug excretion in breast milk.

Precautions & Warnings

Ciclopirox Olamine Shampoo is intended solely for topical use and should not be applied to the eyes, taken orally, or used intravaginally.

Use in Special Populations

Clinical trials have not been conducted on subjects under the age of 16.

Therapeutic Class

Topical Antifungal Preparations

Storage Conditions

Store in a cool, dry place away from light and moisture, at temperatures below 30°C. Keep out of reach of children.