Camlodin Plus 5/50

Indications

This medication is recommended for use in:

• Individuals diagnosed with essential hypertension.
• Patients with both angina pectoris and hypertension as concurrent conditions.
• Post-myocardial infarction (MI) patients.
• Patients experiencing refractory angina pectoris where nitrate therapy has been ineffective.

Pharmacology

This formulation comprises a fixed-dose combination of Amlodipine and Atenolol. Amlodipine, a dihydropyridine calcium antagonist, inhibits the influx of calcium ions into vascular and cardiac muscle, exerting a stronger effect on vascular smooth muscle. Amlodipine acts as a peripheral vasodilator, reducing peripheral vascular resistance and blood pressure by directly affecting vascular smooth muscle. It also decreases coronary vasoreactivity and cardiac demand by reducing afterload.

Atenolol, a cardioselective beta-blocker, reduces blood pressure by lowering cardiac output, plasma renin activity, and sympathetic outflow from the central nervous system (CNS). It also diminishes myocardial oxygen demand through negative inotropic and chronotropic effects.

Dosage & Administration

The recommended dosage is one tablet of Amlodipine and Atenolol (5/25 mg) once daily. If necessary, dosage may be increased to two tablets daily or adjusted as per physician’s advice, with individualization of dosage.

Interactions

Interactions may occur with drugs such as Disopyramide and Ampicillin, affecting their clearance or levels. Beta-blockers like Atenolol may impact insulin sensitivity and secretion when used concomitantly with oral antidiabetics or insulin.

Contraindications

This medication is contraindicated in individuals with hypersensitivity to either component, sinus bradycardia, second- or higher-degree heart block, cardiogenic shock, hypotension, congestive heart failure, or poor left ventricular function.

Side Effects

The combination of Amlodipine and Atenolol is generally well-tolerated. Common side effects include fatigue, headache, edema, nausea, drowsiness, anxiety, and depression.

Pregnancy & Lactation

Use during pregnancy should be considered only if benefits outweigh potential fetal risks. Breastfeeding is not recommended during treatment with this combination.

Precautions & Warnings

Caution is advised in patients with bronchospasm or renal impairment. Monitoring may be necessary in patients with severe hepatic impairment. Drug withdrawal should be gradual to avoid potential complications.

Overdose Effects

Though rare, overdose may lead to hypotension and, less frequently, congestive cardiac failure. Symptomatic treatment is recommended, including gastric lavage or activated charcoal administration if necessary.

Therapeutic Class

This medication belongs to the class of combined antihypertensive preparations.

Storage Conditions

Store below 30°C, away from light and moisture, and out of reach of children.