Bisocam 2.5+5

Indications

The Bisoprolol & Amlodipine combination is prescribed for managing hypertension as a substitute therapy for patients effectively controlled with the individual products administered concurrently at equivalent doses as separate tablets.

Pharmacology

This combination includes Amlodipine, a calcium antagonist that selectively inhibits calcium ion influx into vascular smooth and cardiac muscle cells, primarily reducing peripheral vascular resistance and blood pressure. Bisoprolol Fumarate, a beta1-selective adrenoceptor blocker, complements this action without significant effects on beta2 receptors involved in bronchial and metabolic regulation.

Dosage & Administration

Recommended dosage is one tablet daily for patients adequately controlled on separate doses of the individual components.

Interactions

Exercise caution with certain medications like verapamil, diltiazem, and others that may interact adversely with this combination.

Contraindications

Avoid use in conditions such as acute heart failure, severe bronchial asthma, and certain cardiac conduction abnormalities.

Side Effects

Common side effects may include dizziness, headache, and gastrointestinal disturbances, while less common effects could involve mood changes or visual disturbances.

Pregnancy & Lactation

Not recommended during pregnancy or breastfeeding.

Precautions & Warnings

Special care is needed in patients with heart failure or impaired liver function. Beta-blockers should be used cautiously in individuals with obstructive airways diseases.

Use in Special Populations

Elderly patients can generally use standard doses, but adjustments may be necessary for those with liver or kidney impairment.

Overdose Effects

Symptoms of overdose may include severe bradycardia or hypotension, requiring supportive care and discontinuation of treatment.

Therapeutic Class

Anti-hypertensive agent.

Storage Conditions

Store below 30°C in a dry place, protected from light and out of reach of children.