Azmasol Resperitory Solution

Indications

Azmasol serves as an effective bronchodilator for managing conditions such as:

• Asthma
• Chronic Bronchitis
• Emphysema
• Other disorders related to airway obstruction

Pharmacology

Salbutamol, a synthetic sympathomimetic drug, primarily activates beta-2 adrenergic receptors. This stimulation leads to bronchodilation by relaxing the smooth muscle fibers in the bronchial passages. The result is enhanced pulmonary function, as evidenced by improved spirometric results.

Dosage & Administration

Salbutamol Tablets or Syrup

Children:

• Ages 2-6: 2.5 ml syrup, 3-4 times daily
• Ages 6-12: 5 ml syrup, 3-4 times daily
• Over 12 years: 5-10 ml syrup, 3-4 times daily or 2-4 mg tablets, 3-4 times daily

Adults: 2-4 mg tablets, 3-4 times daily. The maximum single dose is 8 mg.

Salbutamol Respirator Solution

For Use with a Nebulizer:

• Method 1 (Intermittent Administration):
  • Adults & Elderly: 0.5-1.0 ml salbutamol up to four times a day. Dilute 0.5-1 ml of the solution with 2-4 ml sterile normal saline. Treatment takes about 10 minutes. Up to 40 mg/day may be administered under strict medical supervision in a hospital setting.
  • Children under 12: 0.5 ml solution diluted to 2-4 ml with normal saline. Some children may require up to 1.0 ml of the solution. Administer up to four times a day.
• Method 2 (Continuous Administration): Dilute 1-2 ml of the solution to 100 ml with normal saline. Administer with a nebulizer, adding oxygen if necessary.

Salbutamol Nebulizer Solution

• Adults & Elderly: 2.5-5 mg, up to four times a day. Maximum dosage of 40 mg/day under medical supervision.
• Children under 12: 2.5 mg up to four times a day. A higher dose of up to 5 mg may be used if required.

Salbutamol Injection

• Adults: Prepare an intravenous infusion by diluting 5 mL of Salbutamol (1000 mcg/mL) in 500 mL of an intravenous solution, achieving a concentration of 10 mcg/mL. Infusion rates of 3 to 20 micrograms/minute are typically sufficient. Inspect visually for clarity and discard unused admixtures within 24 hours.
• Children & Adolescents (<18 years): Dosage for pediatric use has not been established due to insufficient data.

Salbutamol Inhalation Capsule

• Adults: For bronchospasm relief, inhale one or two capsules as a single dose. For maintenance or prophylactic therapy, one 200 mcg capsule every 4-6 hours is recommended. If needed, use up to two capsules every 4-6 hours.
• Children: For acute bronchospasm relief and maintenance, one capsule should be administered 3-4 times daily. Inhalation may be increased if necessary.

Exercise-Induced Asthma:

• Adults: 400 mcg 15-30 minutes before exercise.
• Children: 200 mcg 15-30 minutes before exercise.

Always follow the advice of your healthcare provider.

Side Effects

Azmasol may cause mild tremors, palpitations, muscle cramps, tachycardia, tension, headaches, and peripheral vasodilation, particularly after high doses.

Pregnancy & Lactation

Use during pregnancy only if the benefits outweigh potential risks to the fetus. The excretion of Salbutamol in human milk is unknown. Consider the potential for tumorigenicity shown in some animal studies when deciding whether to continue breastfeeding.

Precautions & Warnings

Use Azmasol with caution in individuals with hyperthyroidism, cardiovascular diseases, hypertension, vascular disorders, or aneurysms. High doses may increase susceptibility to digitalis-induced cardiac arrhythmia. Monitor patients with diabetes mellitus or closed-angle glaucoma closely.

Overdose Effects

Overdose symptoms include angina, headache, nausea, vomiting, and tremors. A cardio-selective beta-blocker is the preferred antidote but should be used with caution in patients with bronchospasm history.

Therapeutic Class

Short-acting selective β2-adrenoceptor stimulants.

Storage Conditions

Store below 30°C, protected from light and moisture. Keep out of reach of children.