Ascobex

Indications

Ascobex (Ascorbic Acid) is recommended for:

• Prevention and treatment of scurvy.
• Promoting wound and bone healing.
• Supporting collagen formation in connective tissues.
• Enhancing iron absorption to treat anemia.
• Contributing to hemoglobin and red blood cell production in the bone marrow.
• Boosting the immune system and preventing various viral and bacterial infections.
• Assisting in the treatment and prevention of the common cold.
• Maintaining healthy capillaries, gums, and teeth.

Pharmacology

Ascobex provides essential Ascorbic Acid (Vitamin C), which must be acquired through diet or supplements. This vital nutrient supports tissue repair, adrenal gland function, immune system enhancement, and healthy gums. As an antioxidant, it protects against pollution and infections while reducing cellular damage. As a coenzyme, Vitamin C is crucial for wound healing, drug metabolism, and the metabolism of cholesterol and folic acid. It supports overall health by promoting healthy hair and skin, bolstering the immune system, and ensuring overall well-being.

Dosage & Administration

• Oral Tablets:
  • For scurvy prevention: 1 tablet daily.
  • For scurvy treatment: 1-2 tablets daily, with possible dosage adjustments based on severity.
  • For reducing stroke risk in the elderly: 1-2 tablets daily.
  • General use: 1 tablet daily or as directed by a physician.
  • Maximum safe dosage: 2000 mg daily in divided doses.
• Oral Sachets:
  • 1 sachet daily or as prescribed. Maximum dosage: 2000 mg/day (4 sachets/day).
• Parenteral Administration:
  • Preferred via intramuscular (IM) injection for optimal absorption.
  • For intravenous (IV) use, dilute in a large volume of Normal Saline, Water for Injection, or Glucose to minimize adverse reactions.
  • Average protective dose for adults: 70 to 150 mg daily. For scurvy: 300 mg to 1 g daily.
  • To aid wound healing: 300 to 500 mg daily for a week or ten days pre- and post-operatively. For severe burns, daily doses of 1 to 2 g are recommended. Increased dosages may be required based on individual needs.
• Visual Inspection:
  • Parenteral products should be checked for particulates and discoloration before administration.

Interaction

Ascorbic acid is incompatible with substances such as aminophylline, bleomycin, erythromycin, and several others. It enhances the half-life of paracetamol and improves iron absorption.

Side Effects

Ascobex generally has low toxicity, but high doses may cause diarrhea, abdominal bloating, iron over-absorption, hyperoxaluria, and hyperuricosuria. Excessive intake during pregnancy may lead to fetal abortion.

Pregnancy & Lactation

Ascobex is safe at normal doses during pregnancy, but doses exceeding 5 g/day may cause abortion. It is safe for use during lactation.

Precautions & Warnings

High doses (over 1000 mg daily) during pregnancy can cause scurvy in newborns. It is contraindicated for patients with hyperoxaluria. Ascorbic acid may cause false positive results in tests for glucose, uric acid, creatine, and occult blood.

Therapeutic Class

Vitamin C Preparations

Storage Conditions

Store in a dry place below 30˚C.