Antazol Plus

Indications

This nasal spray is recommended for preventing and treating allergic rhinitis, including conditions like hay fever and perennial rhinitis, when accompanied by nasal congestion.

Pharmacology

Xylometazoline Hydrochloride acts as a sympathomimetic agent with alpha-adrenergic activity. It causes vasoconstriction, thereby reducing nasal congestion and facilitating easier breathing through the nose during colds.

Sodium Cromoglicate primarily acts locally on the nasal mucosa. It prevents the release of allergic reaction mediators such as histamine and slow-reacting substance of anaphylaxis (SRS-A) from sensitized mast cells post-antigen-antibody interaction. The drug does not inhibit the binding of IgE and the specific antigen but suppresses the release of substances like histamine and SRS-A in response to this reaction. It also mildly inhibits Type-III (late allergic, Arthers) reactions.

Dosage

For adults (including the elderly) and children, the recommended dosage is one spray into each nostril, four times daily.

• Use medication as directed by your healthcare provider.

Administration

Instructions for using the nasal spray:

1. Shake the bottle gently and remove the dust cover.
2. Hold the spray with your forefinger and middle finger on either side of the nozzle and your thumb underneath the bottle. Press down until a fine spray appears. If using for the first time or after a week or more of non-use, prime the nasal applicator by pressing it several times until a fine mist is emitted.
3. Gently blow your nose to clear your nostrils.
4. Close one nostril and carefully insert the nasal applicator into the open nostril. Tilt your head forward slightly and keep the spray upright. Inhale through your nose and press the applicator down firmly once to release a spray while inhaling.
5. Exhale through your mouth.
6. Repeat the above steps in the other nostril for subsequent doses.

Cleaning: Clean the nasal spray at least once a week using the following steps:

1. Remove the dust cover.
2. Gently pull off the nasal applicator.
3. Wash the applicator and dust cover with warm water.
4. Shake off excess water and allow them to air dry in a cool place. Avoid exposing them to additional heat.
5. Gently reattach the applicator to the bottle and replace the dust cover.

• Use medication as directed by your healthcare provider.

Contraindications

This nasal spray should not be used in patients with known hypersensitivity to any of its ingredients.

Side Effects

No serious side effects have been reported. Occasionally, mild irritation of the nasal mucosa may occur during initial use. In rare cases, wheezing and chest tightness have been reported with Sodium Cromoglicate solutions alone. Antazol Plus, with its lower dose of Xylometazoline, may cause mild side effects such as nasal irritation, dryness, sneezing, headache, insomnia, drowsiness, and palpitations.

Pregnancy & Lactation

Caution is advised during pregnancy, especially in the first trimester.

Precautions & Warnings

Prolonged or excessive use of decongestants may lead to rebound congestion or drug-induced rhinitis.

Therapeutic Class

Mast Cell Stabilizer

Storage Conditions

Store below 30°C, away from light and moisture, and keep out of reach of children.