Anril Spray

Indications

Anril sublingual spray is prescribed for the immediate relief of angina pectoris attacks due to coronary artery disease, as well as for preventive use.

Description

Anril is an organic nitrate that acts as a vasodilator, affecting both arteries and veins. It is available as a metered dose spray containing 400 mcg of Anril per spray, with 200 metered sprays per container. Anril is administered as spray droplets under the tongue.

Pharmacology

Nitroglycerin primarily relaxes vascular smooth muscle, resulting in vasodilation of both peripheral arteries and veins. This reduces systemic vascular resistance, arterial pressure, and left ventricular end-diastolic pressure.

Dosage

During an angina attack, administer 1 or 2 sprays under the tongue initially, with no more than 3 sprays within a 15-minute period. If chest pain persists, seek immediate medical attention. Prophylactic use may involve administering the spray 5 to 10 minutes before activities that could trigger an acute attack.

Administration

Special Instructions:

• Carry Nitroglycerin Spray at all times, especially for angina patients.
• Use only at the onset of chest pain; avoid routine use.
• Avoid alcohol consumption after using this medication.
• Do not use with sildenafil, vardenafil, or tadalafil to prevent severe blood pressure drops.
• Store safely away from children.

How to Use Nitroglycerin Spray:

• Sit down when an angina attack begins.
• Remove the cap and hold the container upright without shaking.
• Place the container close under the tongue and press the button to spray.
• Do not swallow immediately; avoid water for 5-10 minutes after use.
• Repeat if necessary, and replace the cap securely after use.

Interactions

Combining Anril with alcohol can cause severe hypotension. Avoid concurrent use with certain medications to prevent adverse reactions.

Contraindications

Anril should not be used in patients with hypersensitivity to nitrates or certain medical conditions. Avoid use with phosphodiesterase inhibitors.

Side Effects

Possible side effects include headache, facial flushing, dizziness, nausea, and hypotension.

Pregnancy & Lactation

Use in pregnancy or nursing should be considered only if clearly needed, with caution due to potential risks.

Precautions & Warnings

Monitor patients closely during early myocardial infarction and in those with impaired renal or hepatic function.

Special Populations

Safety and effectiveness in pediatric patients have not been established.

Overdose Effects

Symptoms of overdose may include severe hypotension and other cardiovascular symptoms. Immediate medical attention is required in case of overdose.

Therapeutic Class

Anril belongs to the therapeutic class of nitrates, specifically coronary vasodilators.

Storage Conditions

Keep Anril in a cool, dry place away from light and heat, and out of reach of children.