Ameloss 5

Indications

Ameloss is prescribed for the symptomatic management of mild to moderate Alzheimer’s-type dementia.
Always consult a registered healthcare professional before use.

Pharmacology

Donepezil Hydrochloride is a centrally acting anticholinesterase agent that reversibly binds to acetylcholinesterase, inhibiting its action. This process decreases the breakdown of acetylcholine, resulting in increased acetylcholine levels at cholinergic synapses in the brain.

Dosage & Administration

For optimal results, take 5 mg of Ameloss orally once daily at bedtime. This initial dose should be maintained for at least one month to evaluate clinical responses and achieve steady-state concentrations of donepezil hydrochloride. After one month, if appropriate, the dosage can be increased to 10 mg daily. Ameloss can be taken with or without food, as food does not impact its absorption.
Consult a registered healthcare professional for guidance on use.

Interactions

Avoid using Ameloss with anticholinergic medications that penetrate the brain, such as atropine and benztropine, as they may counteract its effects. Medications like carbamazepine, dexamethasone, phenobarbital, and phenytoin can reduce the effectiveness of donepezil, while ketoconazole, quinidine, and cimetidine may enhance its effects.

Contraindications

Ameloss is contraindicated for individuals with known hypersensitivity to donepezil hydrochloride or other piperidine derivatives.

Side Effects

Ameloss is generally well-tolerated, though some patients may experience mild and transient side effects, including nausea, vomiting, and diarrhea. Less common effects may include insomnia, fatigue, anorexia, muscle cramps, and seizures.

Pregnancy & Lactation

There are insufficient well-controlled studies in pregnant women. Donepezil should only be used during pregnancy if the potential benefits justify any risks to the fetus. The presence of donepezil in human breast milk is unknown, and it is not recommended for nursing mothers.

Precautions & Warnings

Exercise caution in patients with sick sinus syndrome, supraventricular conduction abnormalities, peptic ulcer risk, asthma, or obstructive airway disease, as well as during anesthesia.

Use in Special Populations

For patients with renal or mild to moderate hepatic impairment, the same dosage schedule can be followed, as Ameloss clearance is not significantly affected. There is no documented safety or efficacy for Ameloss in children, so it is not recommended for pediatric use.

Overdose Effects

Overdose symptoms may include nausea, vomiting, and excessive salivation. Severe cases may lead to cholinergic crisis, which can manifest as intense nausea, bradycardia, hypotension, increased muscle weakness, respiratory depression, collapse, and convulsions. General supportive measures should be employed, and hospitalization may be necessary in the event of a cholinergic crisis.

Therapeutic Class

Drugs for Dementia

Storage Conditions

Store Ameloss below 30°C, away from light and moisture, and keep out of reach of children.

Always seek the advice of a registered healthcare professional before starting any medication.