Alice

Alice is a topical solution indicated for treating head lice infestations in patients aged 6 months and older. It is specifically formulated to address the presence of lice on the scalp and in the hair.

Pharmacology

The active ingredient in Alice is Ivermectin, a member of the avermectin class. It exerts its parasiticidal effect by selectively binding to glutamate-gated chloride channels found primarily in invertebrate nerve and muscle cells. This binding increases the permeability of the cell membrane to chloride ions, resulting in hyperpolarization of the nerve or muscle cell, leading to paralysis and eventual death of the parasite. The selectivity of Ivermectin for these channels ensures minimal impact on mammalian cells, as some mammals lack glutamate-gated chloride channels. Additionally, Ivermectin has low affinity for mammalian ligand-gated chloride channels and does not readily cross the blood-brain barrier in humans.

Dosage

Alice is intended for topical use on the scalp and hair and should not be ingested orally, applied to the eyes, or used intravaginally. The recommended dosage involves applying the lotion to dry hair in an amount sufficient to thoroughly coat the hair and scalp. After allowing the lotion to remain for 10 minutes, it should be rinsed off with water. Each tube of Alice is intended for single use, and any unused portion should be discarded immediately. Care should be taken to avoid contact with the eyes during application.

Administration

Before applying Alice, ensure that both the hair and scalp are completely dry. Apply the lotion directly to the dry hair and scalp, ensuring thorough coverage. Massage the lotion into the scalp and throughout the hair, ensuring that each strand is coated from the root to the tip. Allow the lotion to remain on the hair and scalp for the recommended 10 minutes before rinsing off with water. After application, it is important to wash hands thoroughly.

Side Effects

Common side effects associated with Alice may include conjunctivitis, ocular hyperemia, eye irritation, dandruff, dry skin, and a burning sensation on the skin. These side effects are typically mild and transient.

Pregnancy & Lactation

Alice falls under Pregnancy Category C, indicating that there are no adequate and well-controlled studies in pregnant women. It should be used during pregnancy only if the potential benefits justify the potential risks to the fetus. While Ivermectin is excreted in low concentrations in human milk following oral administration, the extent of excretion following topical administration has not been evaluated. Caution should be exercised when using Alice in nursing women.

Precautions & Warnings

Alice should be administered under direct adult supervision to minimize the risk of accidental ingestion, particularly in pediatric patients. To prevent the spread of lice, individuals should avoid direct head-to-head contact with others known to have live lice and refrain from sharing personal items such as combs, brushes, hats, towels, and hair accessories. Additionally, individuals should be checked for lice one week after completing treatment, and appropriate measures should be taken if lice are detected.

Therapeutic Class

Alice belongs to the therapeutic class of miscellaneous topical agents, specifically formulated to address head lice infestations.

Storage Conditions

Alice should be stored away from light and moisture in a dry place and kept out of reach of children. Proper storage helps maintain the stability and efficacy of the product.