Algicid Plus

Indications

Algicid Plus is indicated for the treatment of:

• Gastric reflux
• Heartburn
• Indigestion
• Flatulence related to gastric reflux
• Pregnancy-induced heartburn
• Epigastric and retrosternal discomfort linked to gastric reflux

Use as advised by a registered healthcare professional.

Pharmacology

Algicid Plus is a combination of two effective antacids—Calcium Carbonate and Sodium Bicarbonate—and an Alginate (Sodium Alginate). It works in two primary ways:

• Neutralizes excess stomach acid, providing relief from discomfort and pain.
• Forms a protective barrier over the stomach contents, helping to soothe the burning sensations in the chest.

The product’s action is purely physical and doesn’t rely on systemic absorption. Upon ingestion, the active ingredients react with gastric acid to form an Alginic Acid gel raft with a near-neutral pH. This raft interacts with and caps the acid pocket in the stomach, reducing esophageal acid exposure. It effectively prevents gastro-esophageal reflux for up to 4 hours, safeguarding the esophagus from acid, pepsin, and bile. In severe cases, the raft may reflux into the esophagus, providing a soothing effect. Furthermore, studies show that the raft can trap bile and pepsin, offering additional protection to the esophagus.

Calcium Carbonate neutralizes gastric acid quickly to alleviate indigestion and heartburn, with Sodium Bicarbonate enhancing this effect.

Dosage & Administration

For Oral Suspension:

• Adults & Children (12+ years): 10–20 mL after meals and at bedtime, up to four times a day.
• Children (6–12 years): 5–10 mL after meals and at bedtime, up to four times a day.
• Children under 6 years: Not recommended.
• Elderly: No dose modification required.

Chewable Tablets: Chew thoroughly before swallowing. Recommended dosage:

• Adults & Children (12+ years): 2–4 tablets after meals and at bedtime, up to four times a day.
• Children under 12 years: Only as advised by a healthcare provider.

Hepatic Impairment: No dose adjustment needed.
Renal Insufficiency: Use caution if a salt-restricted diet is necessary.

Always follow the instructions of a registered healthcare professional.

Interactions

Allow a 2-hour gap between taking Algicid Plus and other medications, particularly:

• Tetracyclines, Digoxin, Fluoroquinolones, Iron salts, Ketoconazole
• Neuroleptics, Thyroid hormones, Penicillamine, Beta-blockers (Atenolol, Metoprolol, Propranolol)
• Glucocorticoids, Chloroquine, Biphosphonates (e.g., diphosphonates), Estramustine

Contraindications

Algicid Plus should not be used by individuals who are hypersensitive to any of the active ingredients or other components of the formulation.

Side Effects

Possible side effects include:

• Constipation
• Flatulence
• Stomach cramps or belching

If any of these occur, consult a healthcare provider. Overdosing may lead to abdominal bloating. In such cases, seek medical advice.

Pregnancy & Lactation

Pregnancy: Studies involving over 500 pregnant women and post-marketing data have shown no evidence of malformative effects or fetal/neonatal toxicity. Algicid Plus is considered safe for use during pregnancy when clinically necessary.
Breastfeeding: No adverse effects on breastfed infants have been reported. It is safe to use during breastfeeding.
Fertility: Preclinical studies show no adverse effects on fertility or reproduction. There’s no evidence to suggest any impact on human fertility.

Precautions & Warnings

• Each 20 mL dose contains 254.5 mg of sodium (11.06 mmol). Patients on a restricted sodium diet, such as those with congestive heart failure or renal impairment, should consider this.
• Each 20 mL contains 260 mg (6.5 mmol) of calcium. Caution is advised in patients with hypercalcemia, nephrocalcinosis, or recurrent calcium-containing kidney stones.
• Not recommended for children under 12 years, unless prescribed by a doctor.
• Due to the aspartame content, avoid use in patients with phenylketonuria.
• Prolonged use (over 7 days) or masking more serious medical conditions should be done under medical supervision.

Overdose Effects

In case of overdose, symptomatic treatment is recommended. Abdominal distension may occur, and medical advice should be sought if symptoms persist.

Therapeutic Class

Antacids

Storage Conditions

Store below 30°C in a dry place, away from light. Keep out of reach of children. Do not refrigerate or freeze.