Alacot

Indications

Patadin Eye Drops:
Patadin eye drops are recommended for managing the symptoms associated with allergic conjunctivitis, including itchy, watery, red, and swollen eyes and/or eyelids. This includes conditions such as vernal keratoconjunctivitis, vernal keratitis, blepharitis, blepharoconjunctivitis, and giant papillary conjunctivitis.

Alacot Nasal Spray:
Alacot Nasal Spray, an H1 receptor antagonist, is indicated for alleviating the symptoms of seasonal allergic rhinitis in both adults and children aged 6 and above.

Alacot Tablet:
Alacot tablet is prescribed for treating allergic rhinitis and allergic skin conditions. It effectively alleviates allergy symptoms such as skin rashes, swelling, hives, itching, sneezing, and a runny or stuffy nose.

Pharmacology
Olopatadine, an antihistamine, functions by inhibiting the action of histamine in the body, thereby reducing allergy symptoms. It treats sneezing, itching, runny nose, and other nasal allergy symptoms.

Mode of Action:
Olopatadine, acting as an anti-allergic agent, stabilizes mast cells, inhibiting the release of histamine and other inflammatory mediators. It acts as a selective antagonist at histamine H1 receptors, effectively blocking the signaling pathway and reducing the release of inflammatory substances.

Pharmacokinetics:
Olopatadine is readily absorbed, with peak plasma concentrations typically observed within 30 minutes to 1 hour after intranasal administration. It exhibits moderate protein binding in human serum and is primarily eliminated through urinary excretion.

Dosage

Eye Drops:

• 0.1%: Administer one drop in each affected eye twice daily, with an interval of 6 to 8 hours.
• 0.2%: Apply one drop in the affected eye once daily.
• 0.7%: Use one drop in each affected eye once daily.

Nasal Spray:

• Adults and Adolescents 12 years of age and older: Administer two sprays per nostril twice daily.
• Children 6 to 11 years of age: Administer one spray per nostril twice daily.

Tablet:

• Adults: Take 1 tablet (5 mg) twice daily, morning and evening.
• Children 7 years and older: Take 1 tablet (5 mg) twice daily.

Administration

Nasal Spray Usage:

• Shake the bottle gently before use.
• Insert the nasal applicator into each nostril and administer the spray as directed.
• Clean the nasal spray weekly as per instructions.

Interactions
Formal drug-drug interaction studies were not conducted for Alacot Nasal Spray. However, interactions involving liver enzymes inhibitors or P450 inhibition are not expected due to olopatadine’s predominantly renal excretion.

Contraindications
It is contraindicated in individuals with a known hypersensitivity to any component of the product.

Side Effects
Potential adverse effects may include headaches, asthenia, blurred vision, burning or stinging sensation, dry eye, among others.

Pregnancy & Lactation
Use of olopatadine during pregnancy or lactation should be undertaken only if the potential benefit justifies the potential risk to the fetus or nursing infant.

Precautions & Warnings
Patients should not wear contact lenses while using Alacot ophthalmic solution. Caution should be exercised in patients using Alacot Nasal Spray to avoid spraying it into the eyes.

Use in Special Populations
No significant differences in safety or effectiveness have been observed in geriatric populations.

Overdose Effects
There is limited information on Alacot overdose; however, excessive use should be avoided.

Therapeutic Class
Ophthalmic Non-Steroid drugs.

Storage Conditions
Store at room temperature and protect from light. Use within one month of opening the bottle.