Povital

Indications

The combination of Vitamin B1, B6, and B12 is prescribed for addressing deficiencies of these essential vitamins. It is effective in managing the following conditions: polyneuropathy of various origins such as diabetic, alcoholic, or toxic neuropathies; neuritis; neuralgia; cervical syndrome; shoulder-arm syndrome; lumbago; sciatica; myalgia; intercostal neuralgia; herpes zoster; trigeminal neuralgia; and as supportive therapy in facial paresis.
Note: Always use this medication as directed by a registered physician.

Composition

• Tablet (film-coated):
  • Vitamin B1 (Thiamine Mononitrate): 100 mg
  • Vitamin B6 (Pyridoxine Hydrochloride): 200 mg
  • Vitamin B12 (Cyanocobalamin): 200 mcg
• Injection (3 ml ampoule):
  • Thiamine Hydrochloride (Vitamin B1): 100 mg
  • Pyridoxine Hydrochloride (Vitamin B6): 100 mg
  • Cyanocobalamin (Vitamin B12): 1000 mcg

Pharmacology

Vitamin B1 facilitates the conversion of carbohydrates, fatty acids, and amino acids into energy, supports nerve health, enhances mood, and strengthens the heart. Vitamin B6 is crucial for red blood cell production, protein synthesis, neurotransmitter formation (e.g., serotonin), and energy release. It also reduces the risk of cardiovascular diseases, alleviates depression, and eases insomnia. Vitamin B12 is vital for cell replication, red blood cell production, and nerve health, helping to prevent anemia, reduce nerve pain, and lower heart disease risks.

Upon oral administration, these vitamins are effectively absorbed, widely distributed across tissues, and excreted via urine when in excess. Thiamine primarily exists as diphosphate within cells, while pyridoxine and its derivatives convert to active forms in the liver. Vitamin B12 is also processed efficiently but requires specific forms for certain neuropathic conditions.

Dosage & Administration

• Tablet: 1-3 tablets daily or as prescribed by a physician.
• Injection:
  • Severe cases: 1 injection daily until symptoms improve, as advised by a physician.
  • Mild cases: 1 injection 2-3 times weekly, administered intramuscularly.
• Pediatric Use: Not recommended due to insufficient information.
  Note: Always follow a registered physician’s guidance.

Drug Interactions

No significant drug interactions have been reported to date.

Contraindications

This preparation is contraindicated in patients undergoing levodopa therapy or those with hypersensitivity to its components.

Side Effects

Generally well-tolerated, though rare allergic reactions may occur.

Pregnancy & Lactation

Oral tablet forms are recommended during pregnancy and breastfeeding. However, due to the presence of benzyl alcohol, injections should be avoided in these periods.

Precautions & Warnings

Cyanocobalamin is not recommended for treating optic neuropathies associated with elevated plasma levels of cyanocobalamin or subacute spinal cord degeneration.

Overdose Effects

At recommended doses, overdose is unlikely. If an overdose occurs, provide symptomatic and supportive care.

Therapeutic Class

• Combined Vitamin Preparations
• Vaccines, Anti-sera & Immunoglobulins

Storage Guidelines

Keep out of children’s reach. Store in a cool, dry place below 25°C, protected from light.