Gabarol CR 82.5

Indications for Gabarol (Pregabalin) Tablets

Gabarol CR (Pregabalin) is used to manage and treat various neuropathic conditions, including:

• Neuropathic pain associated with diabetic peripheral neuropathy
• Postherpetic neuralgia (nerve pain following shingles)
• Adjunctive therapy for partial-onset seizures in patients aged 1 month and older
• Fibromyalgia (widespread muscle pain)
• Neuropathic pain resulting from spinal cord injury

Gabarol CR (Controlled Release) is specifically indicated for:

• Neuropathic pain due to diabetic peripheral neuropathy
• Postherpetic neuralgia

Consult with a registered healthcare professional before using this medication.

Pharmacology of Gabarol

Pregabalin, the active ingredient in Gabarol, is a synthetic derivative of gamma-aminobutyric acid (GABA). Although it does not directly bind to GABAA, GABAB, or benzodiazepine receptors, Pregabalin works by attaching to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system. This mechanism is thought to contribute to its effectiveness in treating neuropathic pain and managing seizures.

Dosage Guidelines

• For Diabetic Peripheral Neuropathy (DPN): Start with 50 mg three times a day (150 mg/day), with a gradual increase up to 300 mg/day based on effectiveness and tolerance. For Gabarol CR, begin with 165 mg once daily, increasing to 330 mg within one week.
• For Postherpetic Neuralgia: Start with 75 mg twice a day or 50 mg three times a day, with a gradual increase to 300 mg/day. In case of insufficient pain relief, increase the dose to 600 mg/day.
• For Fibromyalgia: Begin with 75 mg twice a day (150 mg/day), gradually increasing to 450 mg/day.
• For Neuropathic Pain with Spinal Cord Injury: Start with 75 mg twice a day (150 mg/day), and increase up to 600 mg/day based on individual response.

Dosing adjustments are based on individual needs and should be done under medical supervision.

Administration of Gabarol

• Oral Administration: Gabarol can be taken with or without food. The controlled-release (CR) formulation should be taken after an evening meal. Do not chew, crush, or split the tablets. If a dose is missed, follow the instructions carefully depending on the timing of the next dose.
• Gradual Discontinuation: When stopping Gabarol, reduce the dosage gradually over a period of at least one week to prevent withdrawal symptoms.

Drug Interactions

• Gabarol is unlikely to cause significant pharmacokinetic interactions with other medications.
• Always inform your healthcare provider about all other medications you are taking to avoid potential interactions.

Contraindications and Warnings

• Gabarol is contraindicated in individuals who are hypersensitive to Pregabalin or any of its components.
• Angioedema and severe allergic reactions, including difficulty breathing, may occur. If this happens, discontinue the medication immediately.
• Suicidal thoughts and behavior have been linked with antiepileptic drugs like Gabarol. Close monitoring is recommended, especially during the initial stages of treatment.

Side Effects

The most common side effects of Gabarol include:

• Dizziness and somnolence
• Dry mouth, edema, and blurred vision
• Weight gain, and changes in attention or concentration

In children, weight gain and increased appetite are commonly observed.

Pregnancy & Lactation

• Pregabalin should only be used during pregnancy if the potential benefits outweigh the risks. Always consult your doctor before use.
• Breastfeeding is not recommended while using Gabarol, as small amounts of Pregabalin are passed through breast milk.

Precautions

• Respiratory depression may occur if Gabarol is combined with other CNS depressants.
• Peripheral edema may develop, particularly in patients taking antidiabetic medications (e.g., thiazolidinediones).
• Gradually tapering the dosage over 1 week is essential when discontinuing Gabarol to avoid withdrawal effects.

Overdose Symptoms and Treatment

In case of overdose, signs may include confusion, agitation, drowsiness, or seizures. Supportive care and monitoring are essential, with the option for gastric lavage if necessary.

Storage Recommendations

• Store Gabarol in a cool, dry place (below 30°C), away from light and moisture. Keep it out of the reach of children.