Cytomis 600

Indications for Cytomis

Cytomis is indicated for the following conditions:

• Prophylaxis of gastric and duodenal ulcers in high-risk NSAID users, including the elderly, those with debilitating diseases, or those with a history of ulcers.
• Healing of NSAID-induced gastric and duodenal damage.
• Healing of gastric and duodenal ulcers in patients not using NSAIDs.
• Induction of labor for women with medical indications.
• Prevention and treatment of postpartum hemorrhage.

Note: Always follow the guidance of a registered healthcare professional when using Cytomis.

Pharmacology of Cytomis

Cytomis contains Misoprostol, a compound that is rapidly absorbed and converted into its active form, Misoprostol acid. This active metabolite is responsible for its therapeutic effects, including antisecretory actions (reducing gastric acid secretion) and mucosal protection. Misoprostol increases bicarbonate and mucus production, which helps protect the gastric lining from NSAID-induced damage. The exact mechanism of ulcer prevention is likely due to both its antisecretory and mucosal protective properties.

Dosage & Administration

For Gastric and Duodenal Ulcers (including NSAID-induced):

• Adults: 800 mcg daily (in 2-4 divided doses) with meals and bedtime. Continue treatment for at least 4 weeks, up to 8 weeks if necessary.

For Prophylaxis of NSAID-induced Ulcers:

• Adults: 200 mcg 2-4 times daily, taken with NSAIDs. If not tolerated, reduce to 100 mcg.

For Labor Induction:

• Vaginally: 25 mcg in the posterior fornix, repeat every 6 hours up to a total of 200 mcg.
• Orally: 100 mcg initially, then 100-200 mcg every 4 hours until labor is established (max 6 doses).

For Prevention of Postpartum Hemorrhage:

• Adults: 600 mcg orally immediately following delivery.

For Treatment of Postpartum Hemorrhage:

• Adults: 600 mcg orally or 1000 mcg rectally.

Drug Interactions

• No significant interactions with cardiac, pulmonary, CNS drugs, or NSAIDs.
• Cytomis may be less effective if taken with high doses of antacids.

Contraindications

Cytomis should not be used in the following cases:

• Allergy to prostaglandins or any components of Misoprostol.
• Pregnancy (due to abortifacient properties).

Side Effects

Common side effects of Cytomis include:

• GI-related: Diarrhea, abdominal pain, dyspepsia, nausea, vomiting, flatulence.
• Others: Rash, dizziness, headache.

To minimize diarrhea, take Cytomis with food or at bedtime, and avoid magnesium-containing antacids.

Pregnancy & Lactation

• Cytomis is contraindicated in pregnancy due to its ability to cause uterine contractions and potential for miscarriage.
• Use only in women of childbearing potential if necessary for NSAID therapy and under strict contraceptive measures.
• Misoprostol is excreted into breast milk but has not been extensively studied. Avoid use in breastfeeding mothers.

Precautions & Warnings

• NSAID-induced ulcers: Do not use in pregnant women or those who may become pregnant unless absolutely necessary.
• Labor induction: Only use in women at 38 weeks of gestation or later, with appropriate fetal monitoring. Contraindicated in certain pregnancy complications (e.g., fetal distress, placenta previa).

Use in Special Populations

• Children: Safety and effectiveness in children under 18 years have not been established.

Overdose Effects

• Signs of overdose may include sedation, tremor, abdominal pain, diarrhea, and fever.
• Treatment is supportive therapy; the exact toxic dose is not known.

Therapeutic Class

• Cytomis belongs to the Prostaglandin Analogues class, acting primarily on the uterus.

Storage Conditions

• Store Cytomis in a cool, dry place away from light and moisture.
• Keep out of the reach of children.