Resadol

Indications

This tablet is indicated for the following conditions:

• Management of moderate to moderately severe pain in adults.
• Short-term management (five days or less) of acute pain.

Use as directed by a registered physician.

Pharmacology

This formulation combines Paracetamol and Tramadol for effective pain relief. Paracetamol is known for its analgesic and antipyretic properties, working primarily in the central nervous system (CNS) to raise pain thresholds by inhibiting cyclooxygenase enzymes involved in prostaglandin synthesis. It is one of the safest and most widely used analgesics, well-tolerated and devoid of many aspirin-related side effects.

Tramadol, a synthetic opioid analgesic, operates through multiple mechanisms: it binds to μ-opioid receptors and inhibits the reuptake of norepinephrine and serotonin, contributing to its analgesic effects.

Dosage & Administration

• For moderate to moderately severe pain: The recommended dose is 1-2 tablets every 4 to 6 hours as needed, with a maximum of 8 tablets per day.
• For acute pain management (five days or less): The recommended dose is 2 tablets every 4 to 6 hours as needed, not exceeding 8 tablets per day.

This medication can be taken without regard to meals.

Use as directed by a registered physician.

Contraindications

The combination of Tramadol and Paracetamol should not be used in patients with known hypersensitivity to either component or in situations where opioids are contraindicated.

Side Effects

Potential side effects may include:

• Fatigue
• Dizziness
• Nausea
• Constipation
• Anxiety
• Rash
• Increased sweating

Pregnancy & Lactation

Pregnancy Category C. The safety of this combination during pregnancy has not been established. Use only if the benefits outweigh risks. Not recommended for use in nursing mothers due to insufficient safety data for infants.

Precautions & Warnings

• This medication may impair the ability to perform tasks requiring mental alertness, such as driving.
• Avoid alcohol while using this medication.
• Do not combine with other products containing Tramadol or Paracetamol.

Use in Special Populations

• Pediatrics: Safety and effectiveness not established in children.
• Geriatrics: Use with caution, considering age-related physiological changes.
• Renal Disease: Not studied in patients with renal impairment. Dosing adjustments may be necessary.
• Hepatic Disease: Use is not recommended in patients with hepatic impairment.

Therapeutic Class

Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

Store in a cool, dry place. Do not freeze. Keep out of reach of children.