Moxquin 400

Indications

Moxquin is prescribed for the treatment of:

• Acute Bacterial Sinusitis
• Acute Exacerbation of Chronic Bronchitis
• Community-Acquired Pneumonia
• Uncomplicated and Complicated Skin and Skin Structure Infections
• Complicated Intra-Abdominal Infections
• Pelvic Inflammatory Disease

Always consult a registered healthcare professional before use.

Pharmacology

Moxifloxacin is a fourth-generation synthetic antibiotic belonging to the fluoroquinolone class. It exhibits broad-spectrum activity against various gram-positive and gram-negative bacteria, as well as anaerobic and atypical organisms, including Mycoplasma pneumoniae. The mechanism of action involves the inhibition of topoisomerase II (DNA gyrase) and topoisomerase IV, both of which are essential for bacterial DNA replication, transcription, and repair.

Dosage & Administration

• Acute Bacterial Sinusitis: 400 mg once daily for 7-10 days.
• Acute Exacerbation of Chronic Bronchitis: 400 mg once daily for 5-10 days.
• Community-Acquired Pneumonia: 400 mg once daily for 7-14 days.
• Uncomplicated Skin and Skin Structure Infections: 400 mg once daily for 7 days.
• Complicated Skin and Skin Structure Infections: 400 mg once daily for 7-21 days.
• Complicated Intra-Abdominal Infections: 400 mg once daily for 5-14 days.
• Pelvic Inflammatory Disease: 400 mg once daily for 14 days.

Always consult a registered healthcare professional before use.

Interactions

The absorption of Moxquin may be reduced when taken with antacids, sucralfate, multivitamins, and multivalent cations (such as iron or zinc). Caution is advised as Moxquin can increase the risk of convulsions when used with NSAIDs and may enhance bleeding tendencies when taken with warfarin. Concurrent use of these medications should be avoided.

Contraindications

Moxifloxacin is contraindicated in individuals with a known hypersensitivity to Moxifloxacin or other quinolones.

Side Effects

Common Side Effects: Nausea, vomiting, diarrhea, headache, dizziness.

Pregnancy & Lactation

Moxifloxacin is classified as FDA pregnancy category C. It is not recommended for use during pregnancy or lactation.

Precautions & Warnings

There is an increased risk of tendinitis and tendon rupture with Moxquin. Discontinue use if tendon pain or inflammation occurs. It is contraindicated in patients with known QT interval prolongation, uncorrected hypokalemia, or those receiving Class IA or Class III antiarrhythmic medications.

Use in Special Populations

• Renal or Hepatic Impairment: No dosage adjustment is necessary for patients with renal or hepatic impairment.
• Pediatric Patients: The safety and efficacy of Moxquin in pediatric patients and adolescents under 18 years have not been established.

Therapeutic Class

4-Quinolone Preparations.

Storage Conditions

Store in a cool, dry place away from light and heat. Keep out of reach of children.