Seasonix

Indications

Seasonix is prescribed for managing symptoms related to various allergic conditions, including:

• Perennial allergic rhinitis
• Seasonal allergic rhinitis
• Chronic idiopathic urticaria

Take medication as per the advice of a registered healthcare professional.

Pharmacology

Seasonix contains Levocetirizine Dihydrochloride, the active enantiomer of cetirizine. It’s a next-generation, highly potent, non-sedative antihistamine known for its strong anti-allergic effects. Levocetirizine exhibits twice the H1 receptor affinity compared to cetirizine, providing rapid and long-lasting relief, making it suitable for once-daily dosing.

Dosage & Administration

• Adults and children aged 12 and older: 5 mg once daily.
• Children aged 6 to 11 years: 2.5 mg (half a tablet or 1 teaspoon of oral solution) once daily.
• Children aged 6 months to 5 years: 1.25 mg (half a teaspoon of oral solution) once daily.

Pediatric Use

For children aged 6 months to 17 years with chronic idiopathic urticaria, dosing recommendations are based on efficacy data from adults aged 18 and older.

Geriatric Use

Clinical studies lacked sufficient data to determine whether elderly patients respond differently than younger adults.

Hepatic Impairment

No dosage adjustments are required for individuals with only liver impairment.

Renal Impairment

• Mild (creatinine clearance 50-80 ml/min): 2.5 mg once daily.
• Moderate (creatinine clearance 30-50 ml/min): 2.5 mg every other day.
• Severe (creatinine clearance 10-30 ml/min): 2.5 mg twice per week (administered every 3-4 days).
• End-stage renal disease (creatinine clearance <10 ml/min): Levocetirizine is not recommended, including for patients on hemodialysis.

Take medication as per the advice of a registered healthcare professional.

Drug Interactions

No significant drug interactions have been observed with Seasonix.

Contraindications

Seasonix is contraindicated in individuals with hypersensitivity to levocetirizine, cetirizine, or hydroxyzine. It should not be used by patients with severe renal impairment (creatinine clearance <10 ml/min).

Side Effects

Levocetirizine is generally well tolerated, though some rare side effects may include:

• Headache
• Dry mouth
• Fatigue
• Skin rash

Pregnancy & Lactation

Classified under Pregnancy Category B, there are no adequate studies of levocetirizine use in pregnant women. Due to its excretion in breast milk, it is not recommended for breastfeeding mothers unless deemed necessary.

Precautions & Warnings

• Caution is advised for individuals with epilepsy or those at risk of seizures.
• Use caution in patients with renal impairment.
• Consider the risks when used during pregnancy or lactation.

Overdose Management

No significant adverse reactions have been reported from an overdose. If an overdose occurs, symptomatic and supportive treatment should be provided.

Therapeutic Class

Non-sedating antihistamines.

Storage Guidelines

Store Seasonix in a dry, cool environment, with a temperature below 30°C. Keep it protected from light.