Tycil 250
40.00৳ Strip
- Tycil is a broad-spectrum penicillin used to treat various bacterial infections including ear, throat, respiratory, skin, and urinary tract infections, as well as gonorrhoea and dental abscesses.
- It supports triple therapy for H. pylori infections and duodenal ulcers.
- Effective against ß-lactamase negative bacteria, Tycil inhibits cell wall biosynthesis and is well-absorbed orally.
- Use with caution in those with penicillin allergies and monitor for interactions with other medications.
Brand
|
Beximco Pharmaceuticals Ltd |
|---|---|
Generics
|
Amoxicillin Trihydrate |
Type
|
Capsule |
Indications
Tycil is prescribed for the treatment of infections caused by susceptible ß-lactamase negative bacteria, including:
- Ear, Nose, and Throat Infections: Otitis media, sinusitis, tonsillitis, pharyngitis, laryngitis
- Lower Respiratory Tract Infections: Pneumonia, acute and chronic bronchitis, lung abscess, empyema, bronchiectasis
- Skin and Soft Tissue Infections: Cellulitis, carbuncles, furunculosis, infected wounds, abscesses
- Genito-Urinary Tract Infections: Pyelonephritis, cystitis, urethritis
- Venereal Disease: Acute uncomplicated gonorrhoea
- Dental Abscesses: Short-term therapy
- Triple Therapy: In combination with Clarithromycin and Lansoprazole, for H. pylori infection and duodenal ulcer disease, and to lower duodenal ulcer recurrence risk.
Pharmacology
Amoxicillin is a broad-spectrum penicillin effective against many Gram-positive and Gram-negative bacteria. It works by inhibiting cell wall biosynthesis, is stable in gastric acid, and is rapidly absorbed. Peak plasma concentration is achieved within 1-2 hours post-administration, with widespread distribution throughout body tissues and fluids.
Dosage
- Adults: Start with 250 mg three times daily, increasing to 500 mg three times daily for severe infections.
- Children (up to 10 years): Begin with 125 mg three times daily, increasing to 250 mg three times daily for severe infections.
- Severe or Recurrent Purulent Respiratory Infections: 3 gm every 12 hours.
- Otitis Media: 1 g three times daily for adults; 40 mg/kg body weight daily in three divided doses for children (maximum 3 g daily).
- Pneumonia: 500-1000 mg three times daily.
- Dental Abscess: 3 gm, repeated after 10-12 hours.
- Urinary Tract Infections: 3 gm, repeated after 10-12 hours.
- Gonorrhoea: Single dose of 2-3 gm with Probenecid 1 gm (Probenecid is contraindicated in children under 2 years).
- Renal Impairment: Dosage adjustment may be necessary.
Administration
Reconstituted suspension can be mixed with milk, fruit juice, or water and should be consumed immediately.
Interactions
- Probenecid: May increase and prolong Tycil blood levels.
- Oral Contraceptives: Tycil may affect gut flora, reducing the effectiveness of estrogen/progesterone contraceptives.
Contraindications
Tycil is contraindicated in patients with penicillin hypersensitivity.
Side Effects
Typically mild and transient, including diarrhea, indigestion, and occasional rash. Rarely, pseudo-membranous colitis may occur.
Pregnancy & Lactation
Amoxicillin is FDA category B. Use during pregnancy only if necessary. It is excreted in breast milk; caution is advised for lactating mothers.
Precautions & Warnings
Monitor for superinfections. Discontinue Tycil and initiate appropriate therapy if superinfections occur.
Therapeutic Class
Broad-spectrum penicillins.
Reconstitution
- Intramuscular: Add 2.5 ml water for injection to the vial.
- Intravenous: Dissolve in 10 ml water for injection.
Storage Conditions
Store in a dry place away from light and heat. Keep out of reach of children.
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