Nervalin 75

Indications

Nervalin is prescribed for:

• Neuropathic pain associated with diabetic peripheral neuropathy (DPN)
• Postherpetic neuralgia (PHN)
• As an adjunctive therapy for partial-onset seizures in patients 1 month of age and older
• Fibromyalgia
• Neuropathic pain due to spinal cord injury

Nervalin CR tablet is indicated for:

• Neuropathic pain associated with diabetic peripheral neuropathy (DPN)
• Postherpetic neuralgia (PHN)

Pharmacology

Pregabalin, a structural derivative of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), does not bind directly to GABAA, GABAB, or benzodiazepine receptors. It binds with high affinity to the alpha2-delta site in central nervous system tissues, which is thought to contribute to its anti-nociceptive and antiseizure effects, although the exact mechanism is not fully understood.

Dosage

• Neuropathic pain (DPN) in adults: Start with 50 mg three times daily (150 mg/day), potentially increasing to 300 mg/day within a week. Maximum dose: 100 mg three times daily (300 mg/day). For Pregabalin CR, begin with 165 mg once daily, increasing to 330 mg once daily within a week. Maximum dose: 330 mg once daily.
• Postherpetic neuralgia (PHN) in adults: Start with 75 to 150 mg twice daily or 50 to 100 mg three times daily (150 to 300 mg/day), potentially increasing to 600 mg/day. For Pregabalin CR, begin with 165 mg once daily, increasing to 330 mg once daily within a week. Maximum dose: 660 mg once daily.
• Fibromyalgia in adults: Start with 75 mg twice daily (150 mg/day), potentially increasing to 300 mg/day within a week. Further increase to 450 mg/day if needed.
• Neuropathic pain due to spinal cord injury in adults: Start with 75 mg twice daily (150 mg/day), potentially increasing to 600 mg/day within a week.
• Conversion to Pregabalin CR: Switch from Pregabalin capsules to Pregabalin CR capsule after an evening meal. Follow specific dosage conversion recommendations.

Administration

Pregabalin is taken orally, with or without food. Pregabalin CR tablets should be taken after an evening meal, swallowed whole without splitting, crushing, or chewing. If a dose is missed, it should be taken with the next meal or before bedtime.

Interaction

• Drug interactions: Nervalin is unlikely to have significant pharmacokinetic drug interactions.
• Food and others: Not applicable.

Contraindications

Nervalin is contraindicated in patients with known hypersensitivity to Pregabalin or any of its components.

Side Effects

Common side effects in adults include dizziness, somnolence, dry mouth, edema, blurred vision, weight gain, and difficulty with concentration. In pediatric patients, increased weight and appetite are common.

Pregnancy & Lactation

There are no adequate studies in pregnant women. Pregabalin is found in small amounts in breast milk, and due to potential risks, breastfeeding is not recommended during treatment.

Precautions & Warnings

• Angioedema and hypersensitivity reactions require immediate discontinuation.
• Increased risk of suicidal thoughts or behavior.
• Respiratory depression may occur, especially with concomitant CNS depressants.
• May cause dizziness and somnolence, impairing the ability to drive or operate machinery.
• Gradual discontinuation over at least one week is recommended to avoid increased seizure frequency or adverse reactions.

Use in Special Populations

• Safety and effectiveness in pediatric patients for various conditions have not been established, except for partial-onset seizures in patients over 1 month old.
• Safety for Pregabalin extended-release tablets in pediatric patients has not been established.

Overdose Effects

Symptoms of overdose include reduced consciousness, depression, confusion, agitation, restlessness, seizures, and heart block. General supportive care and monitoring are recommended.

Therapeutic Class

Adjunct and primary anti-epileptic drugs.

Storage Conditions

Store in a cool, dry place (below 30°C), protected from light and moisture, and keep out of the reach of children.

Common Questions about Nervalin 75 mg Capsule

• What is Nervalin 75 mg Capsule?
  • An anticonvulsant used to treat neurotic pain, shingles, seizures, and fibromyalgia.
• How long before I see improvement?
  • Continue until you see improvement in your health conditions.
• Dosage frequency?
  • As prescribed by your doctor.
• Before or after food?
  • After food, in the prescribed dosage.
• Storage and disposal?
  • Store in a cool, dry place in its original packaging, out of reach of children and pets.
• Same way for each disease?
  • No, it works differently for different diseases.
• Duration of use?
  • Depends on the condition; consult your doctor.
• Continue even if feeling fine?
  • Yes, consult your doctor before stopping.
• Can it cause weight gain?
  • Yes, it may cause weight gain. Consult a dietician if needed.

Quick Tips

• Follow the prescribed dose and duration.
• May cause sleepiness; avoid driving or tasks requiring concentration.
• May cause vision changes; inform your doctor if noticed.
• Monitor for mood changes, depression, or suicidal thoughts.
• Do not stop suddenly without consulting your doctor.