Rabeca 20

Indications

Rabeca Gastro-resistant tablets serve as a remedy for various conditions, including:

• Healing active duodenal ulcers and active benign gastric ulcers
• Addressing symptomatic erosive or ulcerative gastro-esophageal reflux disease (GERD)
• Managing GERD for the long term
• Alleviating symptoms of moderate to severe GERD
• Treating Zollinger-Ellison Syndrome
• Assisting in the eradication of Helicobacter pylori in patients with peptic ulcer disease, when used alongside appropriate antibacterial regimens.

Pharmacology

Rabeprazole acts by inhibiting the gastric H+/K+-ATPase at the secretory surface of the gastric parietal cell, thereby suppressing gastric acid secretion. This mechanism earns rabeprazole the characterization of a gastric proton-pump inhibitor.

Dosage

Dosage recommendations vary depending on the condition being treated:

• Active Duodenal Ulcer and Active Benign Gastric Ulcer: 20 mg once daily in the morning. Healing typically occurs within four to six weeks.
• Erosive or Ulcerative Gastro-Esophageal Reflux Disease (GERD): 20 mg once daily for four to eight weeks.
• GERD Maintenance: 20 mg or 10 mg once daily as maintenance therapy.
• Symptomatic GERD: 10 mg once daily, with adjustments based on symptom control.
• Treatment of GERD in pediatric patients: Dosage varies based on weight and age.
• Zollinger-Ellison Syndrome: Starting dose of 60 mg once daily, with potential titration up to 120 mg/day based on individual patient response.

Administration

For once-daily treatments, Rabeprazole tablets should be taken in the morning before eating. Patients should swallow the tablets whole without chewing or crushing them.

Interactions

Rabeca may interact with compounds whose absorption is pH dependent. Co-administration with certain medications like ketoconazole or itraconazole may require monitoring and potential dosage adjustments.

Contraindications

Rabeprazole is contraindicated in individuals with hypersensitivity to the active substance or excipients, as well as in pregnant and breastfeeding women.

Side Effects

Common side effects may include headache, diarrhea, abdominal pain, and dry mouth. While generally well-tolerated, patients should be aware of potential adverse effects and report any concerns to their healthcare provider.

Pregnancy & Lactation

Rabeprazole is classified as US FDA pregnancy category ‘C’. There are limited studies on its effects in pregnant women, so the decision to use it during pregnancy or breastfeeding should be made after considering the potential risks and benefits.

Precautions & Warnings

Patients should be monitored for symptoms of gastric or esophageal malignancy before starting treatment with Rabeca. Long-term use may increase the risk of fractures, particularly in the elderly or those with other risk factors. Patients should also be cautioned about potential drug interactions and advised on proper administration.

Use in Special Populations

Dosage adjustments are not necessary for patients with renal or hepatic impairment. However, Rabeca is not recommended for pediatric use due to limited safety data.

Overdose Effects

Overdose effects of Rabeca are generally minimal and reversible. Treatment should be symptomatic, and patients should seek medical attention if overdose is suspected.

Therapeutic Class

Rabeca belongs to the class of proton pump inhibitors (PPIs), which are used to suppress gastric acid secretion.

Storage Conditions

Store Rabeca below 30°C, away from light and moisture, and out of reach of children.

Chemical Structure

Molecular Formula: C18H21N3O3S Chemical Structure: [Provide the chemical structure image here, if available]

Common Questions about Rabeca 20 mg Tablet

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Quick Tips

• Rabeca is well-tolerated and provides long-lasting relief.
• Avoid eating late at night or before bedtime.
• Report any persistent symptoms to your doctor.
• Long-term use may affect bone health, so ensure an adequate intake of calcium and magnesium.
• Seek medical attention for any concerning symptoms or adverse reactions.