Oxat 20

Indications

Oxat is prescribed for various conditions including Major Depressive Disorder, Obsessive Compulsive Disorder, Panic Disorder, Social Anxiety Disorder, Generalized Anxiety Disorder, and Posttraumatic Stress Disorder.

Pharmacology

The effectiveness of Paroxetine is believed to be associated with increased serotonergic activity in the central nervous system, achieved by inhibiting the reuptake of serotonin (5-hydroxy-tryptamine, 5 HT) by neurons. Clinical studies have shown that Paroxetine blocks serotonin uptake into human platelets at clinically relevant doses. Additionally, in vitro animal studies suggest that Paroxetine is a potent and highly selective inhibitor of neuronal serotonin reuptake, with minimal effects on norepinephrine and dopamine neuronal reuptake. Furthermore, radioligand binding studies indicate low affinity of Paroxetine for various receptors including muscarinic, alpha1, alpha2, beta adrenergic, dopamine (D2), 5-HT1, 5 HT2, and histamine (H1)-receptors. The metabolites of Paroxetine are substantially less potent than the parent compound.

Dosage & Administration

For Major Depressive Disorder, the usual initial dosage is 20 mg/day, with the option of increasing in 10 mg/day increments, up to a maximum of 50 mg/day. Similar dosage adjustments are recommended for other indications such as Obsessive Compulsive Disorder, Panic Disorder, Social Anxiety Disorder, Generalized Anxiety Disorder, and Posttraumatic Stress Disorder.

Interactions

Oxat may interact with various substances including tryptophan, drug metabolizing enzyme inducers/inhibitors, alcohol, haloperidol, amylobarbitone, oxazepam, MAOIs, lithium, phenytoin, anticonvulsants, and warfarin. Caution is advised when combining Oxat with these substances due to potential interactions.

Contraindications

Concurrent use of Oxat with monoamine oxidase inhibitors (MAOIs) or thioridazine is contraindicated. Additionally, individuals with hypersensitivity to Paroxetine should not use Oxat.

Side Effects

Side effects of Oxat may include various symptoms such as asthenia, sweating, nausea, decreased appetite, somnolence, dizziness, insomnia, tremor, nervousness, ejaculatory disturbance, dry mouth, constipation, impotence, abnormal ejaculation, and female genital disorders.

Pregnancy & Lactation

Use of Oxat during pregnancy should be carefully considered, weighing the potential benefits against the risks to the fetus. It is secreted in human milk, so caution is advised when administered to nursing mothers.

Precautions & Warnings

Special precautions are recommended for patients with cardiac conditions, epilepsy, and those prone to seizures. Caution should also be exercised regarding the ability to drive or operate machinery while using Oxat. Discontinuation of Oxat should be gradual to minimize withdrawal symptoms.

Use in Special Populations

Dosage adjustments are necessary for elderly patients, debilitated patients, and those with severe renal or hepatic impairment.

Therapeutic Class

Oxat belongs to the class of SSRIs & related antidepressant drugs.

Storage Conditions

Oxat should be stored in a cool, dry place, protected from light and moisture, and kept out of the reach of children.