Acetram

Indications

This tablet serves for:

• Managing moderate to moderately severe pain in adults.
• Short-term (five days or less) management of acute pain.

Pharmacology

Paracetamol possesses analgesic and antipyretic properties with mild anti-inflammatory effects. Acting primarily in the CNS, it raises the pain threshold by inhibiting various cyclooxygenase enzymes involved in prostaglandin synthesis. Paracetamol, a para aminophenol derivative, is recognized for its analgesic and antipyretic efficacy with minimal inflammatory impact. It stands out as one of the most widely used, safe, and fast-acting analgesics, well-tolerated with fewer side effects compared to aspirin.

Tramadol, a centrally acting synthetic opioid analgesic, operates through mechanisms not entirely elucidated. Animal studies suggest two complementary mechanisms: binding to μ-opioid receptors by both the parent compound and its M1 metabolite, along with weak inhibition of norepinephrine and serotonin reuptake. These actions contribute to its overall analgesic profile.

Dosage & Administration

For moderate to moderately severe pain management: Take 1 or 2 tablets every 4 to 6 hours as needed, up to a maximum of 8 tablets per day.

For short-term (five days or less) management of acute pain: Take 2 tablets every 4 to 6 hours as needed, up to a maximum of 8 tablets per day. These tablets can be taken regardless of food intake.

Contraindications

Avoid administering Tramadol & Paracetamol combination tablets to individuals with known hypersensitivity to tramadol, paracetamol, or any component of the product, or in situations where opioids are contraindicated.

Side Effects

Possible adverse reactions include asthenia, fatigue, dizziness, gastrointestinal disturbances, and neuropsychiatric symptoms.

Pregnancy & Lactation

Pregnancy Category C. Limited data exist regarding its safety in pregnant women; therefore, use during pregnancy should be justified by potential benefits outweighing risks. Caution is advised in nursing mothers due to insufficient data on its safety in infants.

Precautions & Warnings

Users should avoid alcohol consumption while taking this medication and should not combine it with other tramadol or paracetamol-containing products, including over-the-counter preparations. Caution is advised when using Acetram with other medications affecting mental or physical abilities, and in special populations such as pediatric and geriatric patients.

Therapeutic Class

Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

Store in a cool, dry place, away from children.